3rwm

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[[Image:3rwm.png|left|200px]]
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==Crystal Structure of Ypt32 in Complex with GppNHp==
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<StructureSection load='3rwm' size='340' side='right' caption='[[3rwm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rwm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RWM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rwo|3rwo]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YGL210W, YPT11, YPT32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rwm RCSB], [http://www.ebi.ac.uk/pdbsum/3rwm PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Rab GTPases localize to distinct sub-cellular compartments and regulate vesicle trafficking in eukaryotic cells. Yeast Rabs Ypt31/32 and Sec4 have 68% homology and bind to common interactors, yet play distinct roles in the transport of exocytic vesicles. The structures of Ypt31/32 have not previously been reported in the uncomplexed state. We describe the crystal structures of GTP and GDP forms of Ypt32 to understand the molecular basis for Rab function. The structure of Ypt32(GTP) reveals that the switch II conformation is distinct from Sec4(GTP) in spite of a highly conserved amino acid sequence. Also, Ypt32(GDP) reveals a remarkable change in conformation of the switch II helix induced by binding to GDI, which has not been described previously.
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{{STRUCTURE_3rwm| PDB=3rwm | SCENE= }}
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The activation cycle of Rab GTPase Ypt32 reveals structural determinants of effector recruitment and GDI binding.,Sultana A, Jin Y, Dregger C, Franklin E, Weisman LS, Khan AR FEBS Lett. 2011 Oct 20. PMID:22024479<ref>PMID:22024479</ref>
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===Crystal Structure of Ypt32 in Complex with GppNHp===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22024479}}
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==About this Structure==
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[[3rwm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWM OCA].
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==See Also==
==See Also==
*[[GTP-binding protein|GTP-binding protein]]
*[[GTP-binding protein|GTP-binding protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022024479</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Dregger, C.]]
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[[Category: Dregger, C]]
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[[Category: Franklin, E.]]
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[[Category: Franklin, E]]
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[[Category: Jin, Y.]]
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[[Category: Jin, Y]]
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[[Category: Khan, A R.]]
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[[Category: Khan, A R]]
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[[Category: Sultana, A.]]
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[[Category: Sultana, A]]
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[[Category: Weisman, L S.]]
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[[Category: Weisman, L S]]
[[Category: Effector]]
[[Category: Effector]]
[[Category: Gppnhp]]
[[Category: Gppnhp]]

Revision as of 13:37, 9 December 2014

Crystal Structure of Ypt32 in Complex with GppNHp

3rwm, resolution 2.00Å

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