3p4k
From Proteopedia
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| - | [[ | + | ==The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution== |
| + | <StructureSection load='3p4k' size='340' side='right' caption='[[3p4k]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3p4k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P4K FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mapk14, Crk1, Csbp1, Csbp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p4k RCSB], [http://www.ebi.ac.uk/pdbsum/3p4k PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | MAPKs engage substrates, MAP2Ks, and phosphatases via a docking groove in the C-terminal domain of the kinase. Prior crystallographic studies on the unphosphorylated MAPKs p38alpha and ERK2 defined the docking groove and revealed long-range conformational changes affecting the activation loop and active site of the kinase induced by peptide. Solution NMR data presented here for unphosphorylated p38alpha with a MEK3b-derived peptide (p38alpha/pepMEK3b) validate these findings. Crystallograhic data from doubly phosphorylated active p38alpha (p38alpha/T *GY */pepMEK3b) reveal a structure similar to unphosphorylated p38alpha/MEK3b, and distinct from phosphorylated p38gamma (p38gamma/T *GY *) and ERK2 (ERK2/T *EY *). The structure supports the idea that MAP kinases adopt three distinct conformations: unphosphorylated, phosphorylated, and a docking peptide-induced form. | ||
| - | + | The third conformation of p38alpha MAP kinase observed in phosphorylated p38alpha and in solution.,Akella R, Min X, Wu Q, Gardner KH, Goldsmith EJ Structure. 2010 Dec 8;18(12):1571-8. PMID:21134636<ref>PMID:21134636</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]] | *[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Mitogen-activated protein kinase]] | [[Category: Mitogen-activated protein kinase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Akella, R | + | [[Category: Akella, R]] |
| - | [[Category: Gardner, K H | + | [[Category: Gardner, K H]] |
| - | [[Category: Goldsmith, E J | + | [[Category: Goldsmith, E J]] |
| - | [[Category: Min, X | + | [[Category: Min, X]] |
| - | [[Category: Wu, Q | + | [[Category: Wu, Q]] |
[[Category: Kinase]] | [[Category: Kinase]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 13:43, 9 December 2014
The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution
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