1npa

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[[Image:1npa.jpg|left|200px]]<br /><applet load="1npa" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1npa.jpg|left|200px]]
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caption="1npa, resolution 2.&Aring;" />
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'''crystal structure of HIV-1 protease-hup'''<br />
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{{Structure
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|PDB= 1npa |SIZE=350|CAPTION= <scene name='initialview01'>1npa</scene>, resolution 2.&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=3NH:(3S)-TETRAHYDROFURAN-3-YL (1R,2S)-3-[4-((1R)-2-{[(S)-AMINO(HYDROXY)METHYL]OXY}-2,3-DIHYDRO-1H-INDEN-1-YL)-2-BENZYL-3-OXOPYRROLIDIN-2-YL]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>3NH</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
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|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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}}
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'''crystal structure of HIV-1 protease-hup'''
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==About this Structure==
==About this Structure==
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1NPA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=3NH:'>3NH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPA OCA].
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1NPA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPA OCA].
==Reference==
==Reference==
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An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex., Smith AB 3rd, Hirschmann R, Pasternak A, Yao W, Sprengeler PA, Holloway MK, Kuo LC, Chen Z, Darke PL, Schleif WA, J Med Chem. 1997 Aug 1;40(16):2440-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9258349 9258349]
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An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex., Smith AB 3rd, Hirschmann R, Pasternak A, Yao W, Sprengeler PA, Holloway MK, Kuo LC, Chen Z, Darke PL, Schleif WA, J Med Chem. 1997 Aug 1;40(16):2440-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9258349 9258349]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: protease]]
[[Category: protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:08:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:59:52 2008''

Revision as of 10:59, 20 March 2008

Image:1npa.jpg


PDB ID 1npa

Drag the structure with the mouse to rotate
, resolution 2.Å
Ligands:
Gene: POL (Human immunodeficiency virus 1)
Activity: HIV-1 retropepsin, with EC number 3.4.23.16
Coordinates: save as pdb, mmCIF, xml



crystal structure of HIV-1 protease-hup


About this Structure

1NPA is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex., Smith AB 3rd, Hirschmann R, Pasternak A, Yao W, Sprengeler PA, Holloway MK, Kuo LC, Chen Z, Darke PL, Schleif WA, J Med Chem. 1997 Aug 1;40(16):2440-4. PMID:9258349

Page seeded by OCA on Thu Mar 20 12:59:52 2008

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