1npo
From Proteopedia
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| - | [[Image:1npo.gif|left|200px]] | + | [[Image:1npo.gif|left|200px]] |
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| - | '''BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN''' | + | {{Structure |
| + | |PDB= 1npo |SIZE=350|CAPTION= <scene name='initialview01'>1npo</scene>, resolution 3.0Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1NPO is a [ | + | 1NPO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPO OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the neurophysin-oxytocin complex., Rose JP, Wu CK, Hsiao CD, Breslow E, Wang BC, Nat Struct Biol. 1996 Feb;3(2):163-9. PMID:[http:// | + | Crystal structure of the neurophysin-oxytocin complex., Rose JP, Wu CK, Hsiao CD, Breslow E, Wang BC, Nat Struct Biol. 1996 Feb;3(2):163-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8564543 8564543] |
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: hypothalamus]] | [[Category: hypothalamus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:00:00 2008'' |
Revision as of 11:00, 20 March 2008
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| , resolution 3.0Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN
Overview
The first crystal structure of the pituitary hormone oxytocin complexed with its carrier protein neurophysin has been determined and refined to 3.0 A resolution. The hormone-binding site is located at the end of a 3(10)-helix and involves residues from both domains of each monomer. Hormone residues Tyr 2, which is buried deep in the binding pocket, and Cys 1 have been confirmed as the key residues involved in neurophysin-hormone recognition. We have compared the bound oxytocin observed in the neurophysin-oxytocin complex, the X-ray structures of unbound oxytocin analogues and the NMR-derived structure for bound oxytocin. We find that while our structure is in agreement with the previous crystallographic findings, it differs from the NMR result with regard to how Tyr 2 of the hormone is recognized by neurophysin.
About this Structure
1NPO is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the neurophysin-oxytocin complex., Rose JP, Wu CK, Hsiao CD, Breslow E, Wang BC, Nat Struct Biol. 1996 Feb;3(2):163-9. PMID:8564543
Page seeded by OCA on Thu Mar 20 13:00:00 2008
