4atp
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==Structure of GABA-transaminase A1R958 from Arthrobacter aurescens in complex with PLP== |
| + | <StructureSection load='4atp' size='340' side='right' caption='[[4atp]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4atp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Arthrobacter_aurescens_tc1 Arthrobacter aurescens tc1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ATP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ATP FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-aminobutyrate_transaminase 4-aminobutyrate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.19 2.6.1.19] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4atp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4atp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4atp RCSB], [http://www.ebi.ac.uk/pdbsum/4atp PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Two complex structures of the gamma-aminobutyrate (GABA) transaminase A1R958 from Arthrobacter aurescens TC1 are presented. The first, determined to a resolution of 2.80 A, features the internal aldimine formed by reaction between the -amino group of Lys295 and the cofactor pyridoxal phosphate (PLP); the second, determined to a resolution of 2.75 A, features the external aldimine adduct formed between PLP and GABA in the first half-reaction. This is the first structure of a microbial GABA transaminase in complex with its natural external aldimine and reveals the molecular determinants of GABA binding in this enzyme. | ||
| - | + | Structures of a gamma-aminobutyrate (GABA) transaminase from the s-triazine-degrading organism Arthrobacter aurescens TC1 in complex with PLP and with its external aldimine PLP-GABA adduct.,Bruce H, Nguyen Tuan A, Mangas Sanchez J, Leese C, Hopwood J, Hyde R, Hart S, Turkenburg JP, Grogan G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1175-80., doi: 10.1107/S1744309112030023. Epub 2012 Sep 29. PMID:23027742<ref>PMID:23027742</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: 4-aminobutyrate transaminase]] | [[Category: 4-aminobutyrate transaminase]] | ||
[[Category: Arthrobacter aurescens tc1]] | [[Category: Arthrobacter aurescens tc1]] | ||
| - | [[Category: Bruce, H | + | [[Category: Bruce, H]] |
| - | [[Category: Grogan, G | + | [[Category: Grogan, G]] |
| - | [[Category: Hart, S | + | [[Category: Hart, S]] |
| - | [[Category: Sanchez, J Mangas | + | [[Category: Sanchez, J Mangas]] |
| - | [[Category: Tuan, A N | + | [[Category: Tuan, A N]] |
| - | [[Category: Turkenburg, J P | + | [[Category: Turkenburg, J P]] |
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 15:10, 9 December 2014
Structure of GABA-transaminase A1R958 from Arthrobacter aurescens in complex with PLP
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