3zvo
From Proteopedia
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| - | [[ | + | ==Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3== |
| + | <StructureSection load='3zvo' size='340' side='right' caption='[[3zvo]], [[Resolution|resolution]] 3.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3zvo]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZVO FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zvp|3zvp]], [[1dk1|1dk1]], [[1ibk|1ibk]], [[1f7y|1f7y]], [[1lou|1lou]], [[1ibl|1ibl]], [[2uuc|2uuc]], [[2wdk|2wdk]], [[2y0u|2y0u]], [[1kuq|1kuq]], [[1ab3|1ab3]], [[2j02|2j02]], [[1qjh|1qjh]], [[1j5e|1j5e]], [[2wrq|2wrq]], [[1hnx|1hnx]], [[2j00|2j00]], [[2b9o|2b9o]], [[2x9t|2x9t]], [[2uub|2uub]], [[2wh3|2wh3]], [[2xqd|2xqd]], [[1mvr|1mvr]], [[1cqn|1cqn]], [[1emw|1emw]], [[2v46|2v46]], [[1pnx|1pnx]], [[1qkf|1qkf]], [[1qkh|1qkh]], [[2vqf|2vqf]], [[2y10|2y10]], [[2wh1|2wh1]], [[1n32|1n32]], [[2y18|2y18]], [[2y12|2y12]], [[2wrn|2wrn]], [[2f4v|2f4v]], [[1twt|1twt]], [[2uxd|2uxd]], [[1fka|1fka]], [[1fjg|1fjg]], [[1n36|1n36]], [[2uxc|2uxc]], [[1hnw|1hnw]], [[1l1u|1l1u]], [[1hr0|1hr0]], [[2v48|2v48]], [[2xuy|2xuy]], [[1an7|1an7]], [[2b64|2b64]], [[1xmq|1xmq]], [[2b9m|2b9m]], [[2wdg|2wdg]], [[1xnr|1xnr]], [[1hnz|1hnz]], [[2wdh|2wdh]], [[1jgq|1jgq]], [[1i94|1i94]], [[1cqm|1cqm]], [[2xsy|2xsy]], [[1i96|1i96]], [[2uu9|2uu9]], [[1eg0|1eg0]], [[1vox|1vox]], [[1ibm|1ibm]], [[2uxb|2uxb]], [[2vqe|2vqe]], [[1g1x|1g1x]], [[2bvz|2bvz]], [[1i95|1i95]], [[2uua|2uua]], [[1voz|1voz]], [[1xnq|1xnq]], [[2xfz|2xfz]], [[2bxj|2bxj]], [[1gix|1gix]], [[1jgo|1jgo]], [[1jgp|1jgp]], [[2xg1|2xg1]], [[2x9r|2x9r]], [[1n34|1n34]], [[2y0w|2y0w]], [[1n33|1n33]], [[2jl7|2jl7]], [[1pns|1pns]], [[1yl4|1yl4]], [[2y0y|2y0y]], [[1ris|1ris]], [[2wdm|2wdm]], [[1xmo|1xmo]], [[2y14|2y14]], [[1i97|1i97]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zvo RCSB], [http://www.ebi.ac.uk/pdbsum/3zvo PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Protein release factor 3 (RF3), a guanosine triphosphatase, binds to ribosome after release of the nascent peptide and promotes dissociation of the class I release factors during the termination of protein synthesis. Here we present the crystal structure of the 70S ribosome with RF3 in the presence of a nonhydrolyzable GTP analogue, guanosine 5'-beta,gamma-methylenetriphosphate (GDPCP), refined to 3.8 A resolution. The structure shows that the subunits of the ribosome are rotated relative to each other compared to the canonical state, resulting in a P/E hybrid state for the transfer RNA. The substantial conformational rearrangements in the complex are described and suggest how RF3, by stabilizing the hybrid state of the ribosome, facilitates the dissociation of class I release factors. | ||
| - | + | Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3.,Jin H, Kelley AC, Ramakrishnan V Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15798-803. Epub 2011 Sep 8. PMID:21903932<ref>PMID:21903932</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
| - | *[[Ribosomal protein S10|Ribosomal protein S10]] | ||
| - | *[[Ribosomal protein S11|Ribosomal protein S11]] | ||
| - | *[[Ribosomal protein S12|Ribosomal protein S12]] | ||
| - | *[[Ribosomal protein S13|Ribosomal protein S13]] | ||
| - | *[[Ribosomal protein S14|Ribosomal protein S14]] | ||
| - | *[[Ribosomal protein S15|Ribosomal protein S15]] | ||
| - | *[[Ribosomal protein S16|Ribosomal protein S16]] | ||
| - | *[[Ribosomal protein S17|Ribosomal protein S17]] | ||
| - | *[[Ribosomal protein S18|Ribosomal protein S18]] | ||
| - | *[[Ribosomal protein S19|Ribosomal protein S19]] | ||
| - | *[[Ribosomal protein S2|Ribosomal protein S2]] | ||
| - | *[[Ribosomal protein S20|Ribosomal protein S20]] | ||
| - | *[[Ribosomal protein S3|Ribosomal protein S3]] | ||
| - | *[[Ribosomal protein S4|Ribosomal protein S4]] | ||
| - | *[[Ribosomal protein S5|Ribosomal protein S5]] | ||
| - | *[[Ribosomal protein S6|Ribosomal protein S6]] | ||
| - | *[[Ribosomal protein S7|Ribosomal protein S7]] | ||
| - | *[[Ribosomal protein S8|Ribosomal protein S8]] | ||
| - | *[[Ribosomal protein S9|Ribosomal protein S9]] | ||
*[[Ribosomal protein THX|Ribosomal protein THX]] | *[[Ribosomal protein THX|Ribosomal protein THX]] | ||
| - | + | *[[Ribosome 3D structures|Ribosome 3D structures]] | |
| - | == | + | == References == |
| - | < | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
| - | [[Category: Jin, H | + | [[Category: Jin, H]] |
| - | [[Category: Kelley, A C | + | [[Category: Kelley, A C]] |
| - | [[Category: Ramakrishnan, V | + | [[Category: Ramakrishnan, V]] |
[[Category: Guanosine triphosphatase]] | [[Category: Guanosine triphosphatase]] | ||
[[Category: Hybrid state]] | [[Category: Hybrid state]] | ||
Revision as of 15:27, 9 December 2014
Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3
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