3zr9
From Proteopedia
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| - | [[ | + | ==STRUCTURE OF NEW DELHI METALLO-BETA-LACTAMASE 1 (NDM-1)== |
| + | <StructureSection load='3zr9' size='340' side='right' caption='[[3zr9]], [[Resolution|resolution]] 1.91Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3zr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZR9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zr9 RCSB], [http://www.ebi.ac.uk/pdbsum/3zr9 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo-beta-lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM-1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM-1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM-1. | ||
| - | + | Structure of New Delhi metallo-beta-lactamase 1 (NDM-1).,Green VL, Verma A, Owens RJ, Phillips SE, Carr SB Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt, 10):1160-4. Epub 2011 Sep 6. PMID:22102018<ref>PMID:22102018</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Beta-lactamase|Beta-lactamase]] | *[[Beta-lactamase|Beta-lactamase]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
[[Category: Klebsiella pneumoniae]] | [[Category: Klebsiella pneumoniae]] | ||
| - | [[Category: Carr, S B | + | [[Category: Carr, S B]] |
| - | [[Category: Green, V L | + | [[Category: Green, V L]] |
| - | [[Category: Owens, R J | + | [[Category: Owens, R J]] |
| - | [[Category: Phillips, S E.V | + | [[Category: Phillips, S E.V]] |
| - | [[Category: Verma, A | + | [[Category: Verma, A]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 15:54, 9 December 2014
STRUCTURE OF NEW DELHI METALLO-BETA-LACTAMASE 1 (NDM-1)
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