3v08
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[ | + | ==Crystal structure of Equine Serum Albumin== |
| + | <StructureSection load='3v08' size='340' side='right' caption='[[3v08]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3v08]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V08 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v08 RCSB], [http://www.ebi.ac.uk/pdbsum/3v08 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Serum albumin (SA) is the most abundant plasma protein in mammals. SA is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range of metabolites, drugs, nutrients, metals and other molecules. Due to its ligand binding properties, albumins have wide clinical, pharmaceutical, and biochemical applications. Albumins are also allergenic, and exhibit a high degree of cross-reactivity due to significant sequence and structure similarity of SAs from different organisms. Here we present crystal structures of albumins from cattle (BSA), horse (ESA) and rabbit (RSA) sera. The structural data are correlated with the results of immunological studies of SAs. We also analyze the conservation or divergence of structures and sequences of SAs in the context of their potential allergenicity and cross-reactivity. In addition, we identified a previously uncharacterized ligand binding site in the structure of RSA, and calcium binding sites in the structure of BSA, which is the first serum albumin structure to contain metal ions. | ||
| - | + | Structural and immunologic characterization of bovine, horse, and rabbit serum albumins.,Majorek KA, Porebski PJ, Dayal A, Zimmerman MD, Jablonska K, Stewart AJ, Chruszcz M, Minor W Mol Immunol. 2012 Oct;52(3-4):174-82. Epub 2012 Jun 6. PMID:22677715<ref>PMID:22677715</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
==See Also== | ==See Also== | ||
*[[Albumin|Albumin]] | *[[Albumin|Albumin]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Equus caballus]] | [[Category: Equus caballus]] | ||
| - | [[Category: Almo, S C | + | [[Category: Almo, S C]] |
| - | [[Category: Chruszcz, M | + | [[Category: Chruszcz, M]] |
| - | [[Category: Dayal, A | + | [[Category: Dayal, A]] |
| - | [[Category: Jablonska, K | + | [[Category: Jablonska, K]] |
| - | [[Category: Majorek, K A | + | [[Category: Majorek, K A]] |
| - | [[Category: Minor, W | + | [[Category: Minor, W]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Porebski, P J | + | [[Category: Porebski, P J]] |
[[Category: Allergen]] | [[Category: Allergen]] | ||
[[Category: Carrier protein]] | [[Category: Carrier protein]] | ||
| - | [[Category: New york structural genomics research consortium]] | ||
[[Category: Nysgrc]] | [[Category: Nysgrc]] | ||
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 16:20, 9 December 2014
Crystal structure of Equine Serum Albumin
| |||||||||||
