1o0k

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[[Image:1o0k.gif|left|200px]]<br /><applet load="1o0k" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1o0k.gif|left|200px]]
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caption="1o0k, resolution 1.17&Aring;" />
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'''Structure of the First Parallel DNA Quadruplex-drug Complex'''<br />
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{{Structure
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|PDB= 1o0k |SIZE=350|CAPTION= <scene name='initialview01'>1o0k</scene>, resolution 1.17&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=DM1:DAUNOMYCIN'>DM1</scene> and <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Structure of the First Parallel DNA Quadruplex-drug Complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1O0K is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=DM1:'>DM1</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0K OCA].
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1O0K is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0K OCA].
==Reference==
==Reference==
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Structure of the first parallel DNA quadruplex-drug complex., Clark GR, Pytel PD, Squire CJ, Neidle S, J Am Chem Soc. 2003 Apr 9;125(14):4066-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12670225 12670225]
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Structure of the first parallel DNA quadruplex-drug complex., Clark GR, Pytel PD, Squire CJ, Neidle S, J Am Chem Soc. 2003 Apr 9;125(14):4066-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12670225 12670225]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Clark, G R.]]
[[Category: Clark, G R.]]
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[[Category: parallel quadruplex]]
[[Category: parallel quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:12:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:04:07 2008''

Revision as of 11:04, 20 March 2008

Image:1o0k.gif


PDB ID 1o0k

Drag the structure with the mouse to rotate
, resolution 1.17Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Structure of the First Parallel DNA Quadruplex-drug Complex


Overview

The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5' end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.

About this Structure

1O0K is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Structure of the first parallel DNA quadruplex-drug complex., Clark GR, Pytel PD, Squire CJ, Neidle S, J Am Chem Soc. 2003 Apr 9;125(14):4066-7. PMID:12670225

Page seeded by OCA on Thu Mar 20 13:04:07 2008

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