3zwg
From Proteopedia
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| - | [[ | + | ==Crystal structure of the pore-forming toxin FraC from Actinia fragacea (form 2)== |
| + | <StructureSection load='3zwg' size='340' side='right' caption='[[3zwg]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3zwg]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZWG FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zwj|3zwj]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zwg RCSB], [http://www.ebi.ac.uk/pdbsum/3zwg PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The recent high-resolution structure of the toxin FraC derived from the sea anemone Actinia fragacea has provided new insight into the mechanism of pore formation by actinoporins. In this work, we report two new crystal forms of FraC in its oligomeric prepore conformation. Together with the previously reported structure, these two new structures reveal that ring-like nonamers of the toxin assemble into compact two-dimensional hexagonal arrays. This supramolecular organization is maintained in different relative orientations adopted by the oligomers within the crystal layers. Analyses of the aggregation of FraC pores in both planar and curved (vesicles) model membranes show similar 2D hexagonal arrangements. Our observations support a model in which hexagonal pore-packing is a clustering mechanism that maximizes toxin-driven membrane damage in the target cell. | ||
| - | + | Pores of the toxin FraC assemble into 2D hexagonal clusters in both crystal structures and model membranes.,Mechaly AE, Bellomio A, Morante K, Agirre J, Gil-Carton D, Valle M, Gonzalez-Manas JM, Guerin DM J Struct Biol. 2012 Jun 21. PMID:22728830<ref>PMID:22728830</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Actinia fragacea]] | [[Category: Actinia fragacea]] | ||
| - | [[Category: Bellomio, A | + | [[Category: Bellomio, A]] |
| - | [[Category: Gonzalez-Manas, J M | + | [[Category: Gonzalez-Manas, J M]] |
| - | [[Category: Guerin, D M.A | + | [[Category: Guerin, D M.A]] |
| - | [[Category: Mechaly, A E | + | [[Category: Mechaly, A E]] |
| - | [[Category: Morante, K | + | [[Category: Morante, K]] |
[[Category: Actinoporin]] | [[Category: Actinoporin]] | ||
[[Category: Ion transport]] | [[Category: Ion transport]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 16:22, 9 December 2014
Crystal structure of the pore-forming toxin FraC from Actinia fragacea (form 2)
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