4eox
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor== |
| + | <StructureSection load='4eox' size='340' side='right' caption='[[4eox]], [[Resolution|resolution]] 1.78Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4eox]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EOX FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0S5:N-BENZOYL-1-[(2R)-3-CYCLOPENTYL-2-{[FORMYL(HYDROXY)AMINO]METHYL}PROPANOYL]-L-PROLINAMIDE'>0S5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">def, spr1310 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 Streptococcus pneumoniae R6])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eox OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eox RCSB], [http://www.ebi.ac.uk/pdbsum/4eox PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A new class of PDF inhibitor with potent, broad spectrum antibacterial activity is described. Optimization of blood stability and potency provided compounds with improved pharmacokinetics that were suitable for in vivo experiments. Compound 5c, which has robust antibacterial activity, demonstrated efficacy in two respiratory tract infection models. | ||
| - | + | Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity.,Axten JM, Medina JR, Blackledge CW, Duquenne C, Grant SW, Bobko MA, Peng T, Miller WH, Pinckney T, Gallagher TF, Kulkarni S, Lewandowski T, Van Aller GS, Zonis R, Ward P, Campobasso N Bioorg Med Chem Lett. 2012 Jun 15;22(12):4028-32. Epub 2012 Apr 25. PMID:22579486<ref>PMID:22579486</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Peptide deformylase]] | [[Category: Peptide deformylase]] | ||
[[Category: Streptococcus pneumoniae r6]] | [[Category: Streptococcus pneumoniae r6]] | ||
| - | [[Category: Campobasso, N | + | [[Category: Campobasso, N]] |
| - | [[Category: Ward, P | + | [[Category: Ward, P]] |
[[Category: Alpha-beta]] | [[Category: Alpha-beta]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Peptide deformylase metal ion binding]] | [[Category: Peptide deformylase metal ion binding]] | ||
Revision as of 16:29, 9 December 2014
X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor
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