4fjy
From Proteopedia
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| - | [[ | + | ==Crystal structure of PI3K-gamma in complex with quinoline-indoline inhibitor 24f== |
| + | <StructureSection load='4fjy' size='340' side='right' caption='[[4fjy]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fjy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FJY FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJY:4-[3,3-DIMETHYL-6-(MORPHOLIN-4-YL)-2,3-DIHYDRO-1H-INDOL-1-YL]-7-FLUORO-3-METHYL-2-(PYRIDIN-3-YL)QUINOLINE'>FJY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fjz|4fjz]], [[4flh|4flh]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIK3CG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fjy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fjy RCSB], [http://www.ebi.ac.uk/pdbsum/4fjy PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Structure-based rational design led to the synthesis of a novel series of potent PI3K inhibitors. The optimized pyrrolopyridine analogue 63 was a potent and selective PI3Kbeta/delta dual inhibitor that displayed suitable physicochemical properties and pharmacokinetic profile for animal studies. Analogue 63 was found to be efficacious in animal models of inflammation including a keyhole limpet hemocyanin (KLH) study and a collagen-induced arthritis (CIA) disease model of rheumatoid arthritis. These studies highlight the potential therapeutic value of inhibiting both the PI3Kbeta and delta isoforms in the treatment of a number of inflammatory diseases. | ||
| - | + | Discovery and in Vivo Evaluation of Dual PI3Kbeta/delta Inhibitors.,Gonzalez-Lopez de Turiso F, Shin Y, Brown M, Cardozo M, Chen Y, Fong D, Hao X, He X, Henne K, Hu YL, Johnson MG, Kohn T, Lohman J, McBride HJ, McGee LR, Medina JC, Metz D, Miner K, Mohn D, Pattaropong V, Seganish J, Simard JL, Wannberg S, Whittington DA, Yu G, Cushing TD J Med Chem. 2012 Sep 13;55(17):7667-85. Epub 2012 Aug 29. PMID:22876881<ref>PMID:22876881</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphoinositide 3-Kinases|Phosphoinositide 3-Kinases]] | |
| - | == | + | == References == |
| - | [[ | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Tang, J | + | [[Category: Tang, J]] |
| - | [[Category: Whittington, D A | + | [[Category: Whittington, D A]] |
| - | [[Category: Yakowec, P | + | [[Category: Yakowec, P]] |
[[Category: C2 domain]] | [[Category: C2 domain]] | ||
[[Category: Cancer]] | [[Category: Cancer]] | ||
Revision as of 16:38, 9 December 2014
Crystal structure of PI3K-gamma in complex with quinoline-indoline inhibitor 24f
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Categories: Homo sapiens | Tang, J | Whittington, D A | Yakowec, P | C2 domain | Cancer | Inflammation | Kinase | Leukocyte | P110 | P85 | Phosphotransferase | Transferase-inhibitor complex
