4arb
From Proteopedia
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| - | [[ | + | ==Mus musculus Acetylcholinesterase in complex with (S)-C5685 at 2.25 A resolution.== |
| + | <StructureSection load='4arb' size='340' side='right' caption='[[4arb]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4arb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ARB FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C57:4-(DIMETHYLAMINO)-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-2-METHOXY-5-NITROBENZAMIDE'>C57</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1c2b|1c2b]], [[1c2o|1c2o]], [[1j06|1j06]], [[1j07|1j07]], [[1ku6|1ku6]], [[1maa|1maa]], [[1mah|1mah]], [[1n5m|1n5m]], [[1n5r|1n5r]], [[1q83|1q83]], [[1q84|1q84]], [[2c0p|2c0p]], [[2c0q|2c0q]], [[2h9y|2h9y]], [[2ha0|2ha0]], [[2ha2|2ha2]], [[2ha3|2ha3]], [[2ha4|2ha4]], [[2ha5|2ha5]], [[2ha6|2ha6]], [[2ha7|2ha7]], [[2jey|2jey]], [[2jez|2jez]], [[2jf0|2jf0]], [[2jge|2jge]], [[2jgf|2jgf]], [[2jgg|2jgg]], [[2jgh|2jgh]], [[2jgi|2jgi]], [[2jgj|2jgj]], [[2jgk|2jgk]], [[2jgl|2jgl]], [[2jgm|2jgm]], [[2whp|2whp]], [[2whq|2whq]], [[2whr|2whr]], [[2wls|2wls]], [[2wu3|2wu3]], [[2wu4|2wu4]], [[2xud|2xud]], [[2xuf|2xuf]], [[2xug|2xug]], [[2xuh|2xuh]], [[2xui|2xui]], [[2xuj|2xuj]], [[2xuk|2xuk]], [[2xuo|2xuo]], [[2xup|2xup]], [[2xuq|2xuq]], [[4a16|4a16]], [[4a23|4a23]], [[4ara|4ara]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4arb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4arb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4arb RCSB], [http://www.ebi.ac.uk/pdbsum/4arb PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Take a closer look: Unexpectedly, a pair of enantiomeric ligands proved to have similar binding affinities for acetylcholinesterase. Further studies indicated that the enantiomers exhibit different thermodynamic profiles. Analyses of the noncovalent interactions in the protein-ligand complexes revealed that these differences are partly due to nonclassical hydrogen bonds between the ligands and aromatic side chains of the protein. | ||
| - | + | Similar but Different: Thermodynamic and Structural Characterization of a Pair of Enantiomers Binding to Acetylcholinesterase.,Berg L, Niemiec MS, Qian W, Andersson CD, Wittung-Stafshede P, Ekstrom F, Linusson A Angew Chem Int Ed Engl. 2012 Nov 19. doi: 10.1002/anie.201205113. PMID:23161758<ref>PMID:23161758</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Acetylcholinesterase|Acetylcholinesterase]] | *[[Acetylcholinesterase|Acetylcholinesterase]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Andersson, C D | + | [[Category: Andersson, C D]] |
| - | [[Category: Berg, L | + | [[Category: Berg, L]] |
| - | [[Category: Ekstrom, F | + | [[Category: Ekstrom, F]] |
| - | [[Category: Linusson, A | + | [[Category: Linusson, A]] |
| - | [[Category: Niemiec, M S | + | [[Category: Niemiec, M S]] |
| - | [[Category: Qian, W | + | [[Category: Qian, W]] |
| - | [[Category: Wittungstafshede, P | + | [[Category: Wittungstafshede, P]] |
[[Category: Chemical lead]] | [[Category: Chemical lead]] | ||
[[Category: Enatiomer]] | [[Category: Enatiomer]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
Revision as of 16:41, 9 December 2014
Mus musculus Acetylcholinesterase in complex with (S)-C5685 at 2.25 A resolution.
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