3tvm

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[[Image:3tvm.png|left|200px]]
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==Structure of the mouse CD1d-SMC124-iNKT TCR complex==
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<StructureSection load='3tvm' size='340' side='right' caption='[[3tvm]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tvm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TVM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=07P:N-[(2S,3R)-10-[(1R,2R)-2-DECYLCYCLOPROPYL]-1-(ALPHA-D-GALACTOPYRANOSYLOXY)-3-HYDROXYDECAN-2-YL]HEXACOSANAMIDE'>07P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rzc|3rzc]], [[3t1f|3t1f]], [[3ta3|3ta3]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd1.1, CD1d, Cd1d1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), beta-2-microglobulin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Valpha14 (mouse variable domain, human constant domain) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Vbeta8.2 (mouse variable domain, human constant domain) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tvm RCSB], [http://www.ebi.ac.uk/pdbsum/3tvm PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural killer T (NKT) cells recognize glycolipids presented by CD1d. The first antigen described, alpha-galactosyl ceramide (alphaGalCer), is a potential anticancer agent whose activity depends upon IFN-gamma secretion. We report two analogs of alphaGalCer based on a naturally occurring glycosphingolipid, plakoside A. These compounds induce enhanced IFN-gamma that correlates with detergent-resistant binding to CD1d and an increased stability of the lipid-CD1d complexes on antigen-presenting cells. Structural analysis on one of the analogs indicates that it is more deeply bound inside the CD1d groove, suggesting tighter lipid-CD1d interactions. To our knowledge, this is the first example in which structural information provides an explanation for the increased lipid-CD1d stability, likely responsible for the Th1 bias. We provide insights into the mechanism of IFN-gamma-inducing compounds, and because our compounds activate human NKT cells, they could have therapeutic utility.
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{{STRUCTURE_3tvm| PDB=3tvm | SCENE= }}
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Glycolipids that Elicit IFN-gamma-Biased Responses from Natural Killer T Cells.,Tyznik AJ, Farber E, Girardi E, Birkholz A, Li Y, Chitale S, So R, Arora P, Khurana A, Wang J, Porcelli SA, Zajonc DM, Kronenberg M, Howell AR Chem Biol. 2011 Dec 23;18(12):1620-30. PMID:22195564<ref>PMID:22195564</ref>
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===Structure of the mouse CD1d-SMC124-iNKT TCR complex===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22195564}}
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==About this Structure==
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[[3tvm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TVM OCA].
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==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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*[[CD1|CD1]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:022195564</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Girardi, E.]]
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[[Category: Girardi, E]]
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[[Category: Li, Y.]]
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[[Category: Li, Y]]
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[[Category: Zajonc, D M.]]
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[[Category: Zajonc, D M]]
[[Category: Antigen presentation]]
[[Category: Antigen presentation]]
[[Category: Glycolipid]]
[[Category: Glycolipid]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Nkt cell]]
[[Category: Nkt cell]]

Revision as of 17:09, 9 December 2014

Structure of the mouse CD1d-SMC124-iNKT TCR complex

3tvm, resolution 2.80Å

Drag the structure with the mouse to rotate

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