3tdd
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[ | + | ==Crystal structure of yeast CP in complex with Belactosin C== |
| + | <StructureSection load='3tdd' size='340' side='right' caption='[[3tdd]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3tdd]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TDD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TDD FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFO:BENZYL+N-[(NAPHTHALEN-2-YLMETHOXY)CARBONYL]-L-ALANYL-N~5~-[(2R,3S,4S)-3-FORMYL-2-HYDROXY-4-METHYLHEXANOYL]-L-ORNITHINATE'>BFO</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ryp|1ryp]], [[3e47|3e47]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tdd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tdd RCSB], [http://www.ebi.ac.uk/pdbsum/3tdd PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Successful biochemical studies of the natural products belactosin A and C as well as their more stable acylated derivatives have proved them to be powerful proteasome inhibitors and thereby potential candidates as pharmacologically relevant active compounds. In order to understand their structure-biological activity relations in detail and to find ways of improving their biological activity, four new modified belactosin congeners have been synthesized and tested. One of them (compound 6) turned out to be a more potent inhibitor against HeLa cells than the known proteasome inhibitor MG132. | ||
| - | + | Synthesis and biological activity of optimized belactosin C congeners.,Korotkov VS, Ludwig A, Larionov OV, Lygin AV, Groll M, de Meijere A Org Biomol Chem. 2011 Sep 23. PMID:21946808<ref>PMID:21946808</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
==See Also== | ==See Also== | ||
*[[Proteasome|Proteasome]] | *[[Proteasome|Proteasome]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Proteasome endopeptidase complex]] | [[Category: Proteasome endopeptidase complex]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Groll, M | + | [[Category: Groll, M]] |
| - | [[Category: Korotkov, V S | + | [[Category: Korotkov, V S]] |
| - | [[Category: Larionov, O V | + | [[Category: Larionov, O V]] |
| - | [[Category: Ludwig, A | + | [[Category: Ludwig, A]] |
| - | [[Category: Lygin, A V | + | [[Category: Lygin, A V]] |
| - | [[Category: Meijere, A de | + | [[Category: Meijere, A de]] |
[[Category: Beta-sandwich flanked by alpha-helice]] | [[Category: Beta-sandwich flanked by alpha-helice]] | ||
[[Category: Drug development]] | [[Category: Drug development]] | ||
Revision as of 17:18, 9 December 2014
Crystal structure of yeast CP in complex with Belactosin C
| |||||||||||
Categories: Proteasome endopeptidase complex | Saccharomyces cerevisiae | Groll, M | Korotkov, V S | Larionov, O V | Ludwig, A | Lygin, A V | Meijere, A de | Beta-sandwich flanked by alpha-helice | Drug development | Hydrolase | Hydrolase-hydrolase inhibitor complex | Inhibitor | Primed substrate binding channel | Proteasome | Ubiquitin
