4abr

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[[Image:4abr.png|left|200px]]
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==COMPLEX OF SMPB, A TMRNA FRAGMENT AND EF-TU-GDP-KIRROMYCIN WITH THE 70S RIBOSOME==
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<StructureSection load='4abr' size='340' side='right' caption='[[4abr]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4abr]] is a 27 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ABR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ABR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=KIR:KIRROMYCIN'>KIR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4abs|4abs]], [[1j1h|1j1h]], [[1ibk|1ibk]], [[1ibl|1ibl]], [[2uuc|2uuc]], [[2wdk|2wdk]], [[2y0u|2y0u]], [[2j02|2j02]], [[1j5e|1j5e]], [[2wrq|2wrq]], [[2b9o|2b9o]], [[1hnx|1hnx]], [[2j00|2j00]], [[2x9t|2x9t]], [[2wh3|2wh3]], [[2uub|2uub]], [[1vov|1vov]], [[1wjx|1wjx]], [[1emi|1emi]], [[2xqd|2xqd]], [[1pnx|1pnx]], [[2v46|2v46]], [[2vqf|2vqf]], [[2y10|2y10]], [[2wh1|2wh1]], [[1n32|1n32]], [[2y18|2y18]], [[2y12|2y12]], [[2wrn|2wrn]], [[2f4v|2f4v]], [[1twt|1twt]], [[1qzc|1qzc]], [[2uxd|2uxd]], [[1fka|1fka]], [[1fjg|1fjg]], [[1n36|1n36]], [[2uxc|2uxc]], [[1hnw|1hnw]], [[1l1u|1l1u]], [[1hr0|1hr0]], [[2v48|2v48]], [[2xuy|2xuy]], [[1xmq|1xmq]], [[2b64|2b64]], [[2b9m|2b9m]], [[1pn8|1pn8]], [[2wdg|2wdg]], [[1xnr|1xnr]], [[1dv4|1dv4]], [[1hnz|1hnz]], [[1rss|1rss]], [[2wdh|2wdh]], [[1jgq|1jgq]], [[1i94|1i94]], [[1i96|1i96]], [[2xsy|2xsy]], [[2uu9|2uu9]], [[1pn7|1pn7]], [[1eg0|1eg0]], [[1ibm|1ibm]], [[2uxb|2uxb]], [[3zzp|3zzp]], [[2vqe|2vqe]], [[1g1x|1g1x]], [[1ha3|1ha3]], [[1i95|1i95]], [[2uua|2uua]], [[1xnq|1xnq]], [[2xfz|2xfz]], [[1qd7|1qd7]], [[1gix|1gix]], [[1jgo|1jgo]], [[3zvo|3zvo]], [[1jgp|1jgp]], [[2xg1|2xg1]], [[2czj|2czj]], [[2c78|2c78]], [[2x9r|2x9r]], [[1n34|1n34]], [[1n33|1n33]], [[2y0w|2y0w]], [[1pns|1pns]], [[2jl7|2jl7]], [[1yl4|1yl4]], [[2y0y|2y0y]], [[2wdm|2wdm]], [[1xmo|1xmo]], [[1i97|1i97]], [[2y14|2y14]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4abr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4abr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4abr RCSB], [http://www.ebi.ac.uk/pdbsum/4abr PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In bacteria, ribosomes stalled at the end of truncated messages are rescued by transfer-messenger RNA (tmRNA), a bifunctional molecule that acts as both a transfer RNA (tRNA) and a messenger RNA (mRNA), and SmpB, a small protein that works in concert with tmRNA. Here, we present the crystal structure of a tmRNA fragment, SmpB and elongation factor Tu bound to the ribosome at 3.2 angstroms resolution. The structure shows how SmpB plays the role of both the anticodon loop of tRNA and portions of mRNA to facilitate decoding in the absence of an mRNA codon in the A site of the ribosome and explains why the tmRNA-SmpB system does not interfere with normal translation.
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{{STRUCTURE_4abr| PDB=4abr | SCENE= }}
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Decoding in the absence of a codon by tmRNA and SmpB in the ribosome.,Neubauer C, Gillet R, Kelley AC, Ramakrishnan V Science. 2012 Mar 16;335(6074):1366-9. PMID:22422985<ref>PMID:22422985</ref>
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===COMPLEX OF SMPB, A TMRNA FRAGMENT AND EF-TU-GDP-KIRROMYCIN WITH THE 70S RIBOSOME===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22422985}}
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==About this Structure==
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[[4abr]] is a 27 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ABR OCA].
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==See Also==
==See Also==
*[[Elongation factor|Elongation factor]]
*[[Elongation factor|Elongation factor]]
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*[[Ribosomal protein S10|Ribosomal protein S10]]
 
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*[[Ribosomal protein S11|Ribosomal protein S11]]
 
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*[[Ribosomal protein S12|Ribosomal protein S12]]
 
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*[[Ribosomal protein S13|Ribosomal protein S13]]
 
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*[[Ribosomal protein S14|Ribosomal protein S14]]
 
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*[[Ribosomal protein S15|Ribosomal protein S15]]
 
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*[[Ribosomal protein S16|Ribosomal protein S16]]
 
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*[[Ribosomal protein S17|Ribosomal protein S17]]
 
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*[[Ribosomal protein S18|Ribosomal protein S18]]
 
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*[[Ribosomal protein S19|Ribosomal protein S19]]
 
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*[[Ribosomal protein S2|Ribosomal protein S2]]
 
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*[[Ribosomal protein S20|Ribosomal protein S20]]
 
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*[[Ribosomal protein S3|Ribosomal protein S3]]
 
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*[[Ribosomal protein S4|Ribosomal protein S4]]
 
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*[[Ribosomal protein S5|Ribosomal protein S5]]
 
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*[[Ribosomal protein S6|Ribosomal protein S6]]
 
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*[[Ribosomal protein S7|Ribosomal protein S7]]
 
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*[[Ribosomal protein S8|Ribosomal protein S8]]
 
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*[[Ribosomal protein S9|Ribosomal protein S9]]
 
*[[Ribosomal protein THX|Ribosomal protein THX]]
*[[Ribosomal protein THX|Ribosomal protein THX]]
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*[[Ribosome|Ribosome]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022422985</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Gillet, R.]]
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[[Category: Gillet, R]]
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[[Category: Kelley, A C.]]
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[[Category: Kelley, A C]]
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[[Category: Neubauer, C.]]
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[[Category: Neubauer, C]]
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[[Category: Ramakrishnan, V.]]
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[[Category: Ramakrishnan, V]]
[[Category: Ef-tu]]
[[Category: Ef-tu]]
[[Category: Ribosome]]
[[Category: Ribosome]]
[[Category: Smpb]]
[[Category: Smpb]]
[[Category: Tmrna]]
[[Category: Tmrna]]

Revision as of 17:44, 9 December 2014

COMPLEX OF SMPB, A TMRNA FRAGMENT AND EF-TU-GDP-KIRROMYCIN WITH THE 70S RIBOSOME

4abr, resolution 3.10Å

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