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1o7y
From Proteopedia
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| - | [[Image:1o7y.gif|left|200px]] | + | [[Image:1o7y.gif|left|200px]] |
| - | + | ||
| - | '''CRYSTAL STRUCTURE OF IP-10 M-FORM''' | + | {{Structure |
| + | |PDB= 1o7y |SIZE=350|CAPTION= <scene name='initialview01'>1o7y</scene>, resolution 3.00Å | ||
| + | |SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+C'>AC1</scene> | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF IP-10 M-FORM''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1O7Y is a [ | + | 1O7Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Y OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine., Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR, Structure. 2003 May;11(5):521-32. PMID:[http:// | + | Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine., Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR, Structure. 2003 May;11(5):521-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12737818 12737818] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Acharya, K R.]] | [[Category: Acharya, K R.]] | ||
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[[Category: interferon induction]] | [[Category: interferon induction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:07:01 2008'' |
Revision as of 11:07, 20 March 2008
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| , resolution 3.00Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF IP-10 M-FORM
Overview
We have determined the structure of wild-type IP-10 from three crystal forms. The crystals provide eight separate models of the IP-10 chain, all differing substantially from a monomeric IP-10 variant examined previously by NMR spectroscopy. In each crystal form, IP-10 chains form conventional beta sheet dimers, which, in turn, form a distinct tetrameric assembly. The M form tetramer is reminiscent of platelet factor 4, whereas the T and H forms feature a novel twelve-stranded beta sheet. Analytical ultracentrifugation indicates that, in free solution, IP-10 exists in a monomer-dimer equilibrium with a dissociation constant of 9 microM. We propose that the tetrameric structures may represent species promoted by the binding of glycosaminoglycans. The binding sites for several IP-10-neutralizing mAbs have also been mapped.
About this Structure
1O7Y is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine., Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR, Structure. 2003 May;11(5):521-32. PMID:12737818
Page seeded by OCA on Thu Mar 20 13:07:01 2008
