4as4
From Proteopedia
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| - | [[ | + | ==Structure of human inositol monophosphatase 1== |
| + | <StructureSection load='4as4' size='340' side='right' caption='[[4as4]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4as4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AS4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1awb|1awb]], [[1ima|1ima]], [[1imb|1imb]], [[1imc|1imc]], [[1imd|1imd]], [[1ime|1ime]], [[1imf|1imf]], [[2hhm|2hhm]], [[4as5|4as5]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4as4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4as4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4as4 RCSB], [http://www.ebi.ac.uk/pdbsum/4as4 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Inositol monophosphatase (IMPase) catalyses the hydrolysis of inositol monophosphate to inositol and is crucial in the phosphatidylinositol (PI) signalling pathway. Lithium, which is the drug of choice for bipolar disorder, inhibits IMPase at therapeutically relevant plasma concentrations. Both mouse IMPase 1 (MmIMPase 1) and human IMPase 1 (HsIMPase 1) were cloned into pRSET5a, expressed in Escherichia coli, purified and crystallized using the sitting-drop method. The structures were solved at resolutions of 2.4 and 1.7 A, respectively. Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A. | ||
| - | + | Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.,Singh N, Halliday AC, Knight M, Lack NA, Lowe E, Churchill GC Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1149-52., doi: 10.1107/S1744309112035191. Epub 2012 Sep 22. PMID:23027737<ref>PMID:23027737</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| - | + | ==See Also== | |
| - | + | *[[Inositol Monophosphatase|Inositol Monophosphatase]] | |
| - | == | + | == References == |
| - | [[ | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Inositol-phosphate phosphatase]] | [[Category: Inositol-phosphate phosphatase]] | ||
| - | [[Category: Churchill, G C | + | [[Category: Churchill, G C]] |
| - | [[Category: Halliday, A C | + | [[Category: Halliday, A C]] |
| - | [[Category: Knight, M | + | [[Category: Knight, M]] |
| - | [[Category: Lack, N A | + | [[Category: Lack, N A]] |
| - | [[Category: Lowe, E D | + | [[Category: Lowe, E D]] |
| - | [[Category: Singh, N | + | [[Category: Singh, N]] |
[[Category: Bipolar disorder]] | [[Category: Bipolar disorder]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Lithium]] | [[Category: Lithium]] | ||
Revision as of 17:45, 9 December 2014
Structure of human inositol monophosphatase 1
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