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1o84

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[[Image:1o84.jpg|left|200px]]<br /><applet load="1o84" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1o84.jpg|left|200px]]
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caption="1o84, resolution 2.8&Aring;" />
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'''CRYSTAL STRUCTURE OF BACTERIOCIN AS-48. N-DECYL-BETA-D-MALTOSIDE BOUND.'''<br />
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{{Structure
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|PDB= 1o84 |SIZE=350|CAPTION= <scene name='initialview01'>1o84</scene>, resolution 2.8&Aring;
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|SITE= <scene name='pdbsite=GOL:So4+Binding+Site+For+Chain+B'>GOL</scene>
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|LIGAND= <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=D10:DECANE'>D10</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF BACTERIOCIN AS-48. N-DECYL-BETA-D-MALTOSIDE BOUND.'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1O84 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis] with <scene name='pdbligand=MAL:'>MAL</scene>, <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=D10:'>D10</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=GOL:So4+Binding+Site+For+Chain+B'>GOL</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O84 OCA].
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1O84 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O84 OCA].
==Reference==
==Reference==
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Structure of bacteriocin AS-48: from soluble state to membrane bound state., Sanchez-Barrena MJ, Martinez-Ripoll M, Galvez A, Valdivia E, Maqueda M, Cruz V, Albert A, J Mol Biol. 2003 Nov 28;334(3):541-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14623193 14623193]
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Structure of bacteriocin AS-48: from soluble state to membrane bound state., Sanchez-Barrena MJ, Martinez-Ripoll M, Galvez A, Valdivia E, Maqueda M, Cruz V, Albert A, J Mol Biol. 2003 Nov 28;334(3):541-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14623193 14623193]
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein membrane interaction]]
[[Category: protein membrane interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:14:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:07:04 2008''

Revision as of 11:07, 20 March 2008

Image:1o84.jpg


PDB ID 1o84

Drag the structure with the mouse to rotate
, resolution 2.8Å
Sites:
Ligands: , , and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF BACTERIOCIN AS-48. N-DECYL-BETA-D-MALTOSIDE BOUND.


Overview

The bacteriocin AS-48 is a membrane-interacting peptide, which displays a broad anti-microbial spectrum against Gram-positive and Gram-negative bacteria. The NMR structure of AS-48 at pH 3 has been solved. The analysis of this structure suggests that the mechanism of AS-48 anti-bacterial activity involves the accumulation of positively charged molecules at the membrane surface leading to a disruption of the membrane potential. Here, we report the high-resolution crystal structure of AS-48 and sedimentation equilibrium experiments showing that this bacteriocin is able to adopt different oligomeric structures according to the physicochemical environment. The analysis of these structures suggests a mechanism for molecular function of AS-48 involving a transition from a water-soluble form to a membrane-bound state upon membrane binding.

About this Structure

1O84 is a Single protein structure of sequence from Enterococcus faecalis. Full crystallographic information is available from OCA.

Reference

Structure of bacteriocin AS-48: from soluble state to membrane bound state., Sanchez-Barrena MJ, Martinez-Ripoll M, Galvez A, Valdivia E, Maqueda M, Cruz V, Albert A, J Mol Biol. 2003 Nov 28;334(3):541-9. PMID:14623193

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