3ut5

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[[Image:3ut5.png|left|200px]]
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==Tubulin-Colchicine-Ustiloxin: Stathmin-like domain complex==
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<StructureSection load='3ut5' size='340' side='right' caption='[[3ut5]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ut5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UT5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LOC:N-[(7S)-1,2,3,10-TETRAMETHOXY-9-OXO-6,7-DIHYDRO-5H-BENZO[D]HEPTALEN-7-YL]ETHANAMIDE'>LOC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0E5:(2S,3R)-2-AZANYL-3-METHYL-3-OXIDANYL-PENTANOIC+ACID'>0E5</scene>, <scene name='pdbligand=0EA:(BETAR)-BETA,3-DIHYDROXY-N-METHYL-L-TYROSINE'>0EA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ut5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ut5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ut5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ut5 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Vinca-domain ligands are compounds that bind to tubulin at its inter-heterodimeric interface and favour heterogeneous protofilament-like assemblies, giving rise to helices and rings. This is the basis for their inhibition of microtubule assembly, for their antimitotic activities and for their use in anticancer chemotherapy. Ustiloxins are vinca-domain ligands with a well established total synthesis. A 2.7 A resolution structure of ustiloxin D bound to the vinca domain embedded in the complex of two tubulins with the stathmin-like domain of RB3 (T(2)R) has been determined. This finding precisely defines the interactions of ustiloxins with tubulin and, taken together with structures of other vinca-ligand complexes, allows structure-based suggestions to be made for improved activity. These comparisons also provide a rationale for the large-scale polymorphism of the protofilament-like assemblies mediated by vinca-domain ligands based on local differences in their interactions with the two tubulin heterodimers constituting their binding site.
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{{STRUCTURE_3ut5| PDB=3ut5 | SCENE= }}
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Structural plasticity of tubulin assembly probed by vinca-domain ligands.,Ranaivoson FM, Gigant B, Berritt S, Joullie M, Knossow M Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):927-34. Epub 2012 Jul 7. PMID:22868758<ref>PMID:22868758</ref>
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===Tubulin-Colchicine-Ustiloxin: Stathmin-like domain complex===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22868758}}
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==See Also==
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*[[Tubulin|Tubulin]]
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==About this Structure==
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== References ==
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[[3ut5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UT5 OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Ovis aries]]
[[Category: Ovis aries]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Gigant, B.]]
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[[Category: Gigant, B]]
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[[Category: Knossow, M.]]
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[[Category: Knossow, M]]
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[[Category: Ranaivoson, F M.]]
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[[Category: Ranaivoson, F M]]
[[Category: Microtubule]]
[[Category: Microtubule]]
[[Category: Stathmin]]
[[Category: Stathmin]]

Revision as of 17:48, 9 December 2014

Tubulin-Colchicine-Ustiloxin: Stathmin-like domain complex

3ut5, resolution 2.73Å

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