4g9j
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==Protein Ser/Thr phosphatase-1 in complex with cell-permeable peptide== |
| + | <StructureSection load='4g9j' size='340' side='right' caption='[[4g9j]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4g9j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G9J FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPP1A, PPP1CA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g9j RCSB], [http://www.ebi.ac.uk/pdbsum/4g9j PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The first cell-penetrating peptide that activates protein phosphatase-1 (PP1) by disrupting a subset of PP1 complexes in living cells has been developed. Activated PP1 rapidly dephosphorylates its substrates, counteracting kinase activity inside cells. Activation of PP1 can thus be a novel approach to study PP1 function and to counteract Ser/Thr kinase activity under pathologically increased kinase signaling. | ||
| - | + | Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells.,Chatterjee J, Beullens M, Sukackaite R, Qian J, Lesage B, Hart DJ, Bollen M, Kohn M Angew Chem Int Ed Engl. 2012 Sep 7. doi: 10.1002/anie.201204308. PMID:22962028<ref>PMID:22962028</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| - | + | ==See Also== | |
| - | + | *[[Protein phosphatase|Protein phosphatase]] | |
| - | == | + | *[[Serine/threonine protein phosphatase|Serine/threonine protein phosphatase]] |
| - | [[ | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphoprotein phosphatase]] | [[Category: Phosphoprotein phosphatase]] | ||
| - | [[Category: Beullens, M | + | [[Category: Beullens, M]] |
| - | [[Category: Bollen, M | + | [[Category: Bollen, M]] |
| - | [[Category: Chatterjee, J | + | [[Category: Chatterjee, J]] |
| - | [[Category: Hart, D J | + | [[Category: Hart, D J]] |
| - | [[Category: Koehn, M | + | [[Category: Koehn, M]] |
| - | [[Category: Sukackaite, R | + | [[Category: Sukackaite, R]] |
[[Category: Activating peptide]] | [[Category: Activating peptide]] | ||
[[Category: Hydrolase-hydrolase activator complex]] | [[Category: Hydrolase-hydrolase activator complex]] | ||
[[Category: Protein phosphatase 1]] | [[Category: Protein phosphatase 1]] | ||
[[Category: Rvxf binding motif]] | [[Category: Rvxf binding motif]] | ||
Revision as of 09:07, 10 December 2014
Protein Ser/Thr phosphatase-1 in complex with cell-permeable peptide
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