1oan

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[[Image:1oan.gif|left|200px]]<br /><applet load="1oan" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1oan.gif|left|200px]]
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caption="1oan, resolution 2.75&Aring;" />
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'''CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN'''<br />
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{{Structure
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|PDB= 1oan |SIZE=350|CAPTION= <scene name='initialview01'>1oan</scene>, resolution 2.75&Aring;
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|SITE= <scene name='pdbsite=AC1:Afl+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1OAN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_type_3 Dengue virus type 3] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Afl+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAN OCA].
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1OAN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_type_3 Dengue virus type 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAN OCA].
==Reference==
==Reference==
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A ligand-binding pocket in the dengue virus envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91. Epub 2003 May 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12759475 12759475]
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A ligand-binding pocket in the dengue virus envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91. Epub 2003 May 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12759475 12759475]
[[Category: Dengue virus type 3]]
[[Category: Dengue virus type 3]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: membrane fusion]]
[[Category: membrane fusion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:15:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:08:09 2008''

Revision as of 11:08, 20 March 2008

Image:1oan.gif


PDB ID 1oan

Drag the structure with the mouse to rotate
, resolution 2.75Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN


Overview

Dengue virus is an emerging global health threat. Its major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion. The pocket, which accepts a hydrophobic ligand, opens and closes through a conformational shift in a beta-hairpin at the interface between two domains. These features point to a structural pathway for the fusion-activating transition and suggest a strategy for finding small-molecule inhibitors of dengue and other flaviviruses.

About this Structure

1OAN is a Single protein structure of sequence from Dengue virus type 3. Full crystallographic information is available from OCA.

Reference

A ligand-binding pocket in the dengue virus envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91. Epub 2003 May 20. PMID:12759475

Page seeded by OCA on Thu Mar 20 13:08:09 2008

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