1oau

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[[Image:1oau.jpg|left|200px]]<br /><applet load="1oau" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1oau.jpg|left|200px]]
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caption="1oau, resolution 1.8&Aring;" />
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'''FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH DNP-SER (IMMUNISING HAPTEN)'''<br />
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{{Structure
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|PDB= 1oau |SIZE=350|CAPTION= <scene name='initialview01'>1oau</scene>, resolution 1.8&Aring;
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|SITE= <scene name='pdbsite=AC1:Imd+Binding+Site+For+Chain+N'>AC1</scene>
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|LIGAND= <scene name='pdbligand=SER:SERINE'>SER</scene> and <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH DNP-SER (IMMUNISING HAPTEN)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1OAU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus] with <scene name='pdbligand=SER:'>SER</scene> and <scene name='pdbligand=IMD:'>IMD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Imd+Binding+Site+For+Chain+N'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAU OCA].
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1OAU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAU OCA].
==Reference==
==Reference==
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Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12610298 12610298]
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Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12610298 12610298]
[[Category: Rattus rattus]]
[[Category: Rattus rattus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: multispecificity]]
[[Category: multispecificity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:15:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:08:14 2008''

Revision as of 11:08, 20 March 2008

Image:1oau.jpg


PDB ID 1oau

Drag the structure with the mouse to rotate
, resolution 1.8Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH DNP-SER (IMMUNISING HAPTEN)


Overview

A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre-steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing hapten. A subsequent induced-fit isomerization led to high-affinity complexes with a deep and narrow binding site. A protein antigen identified by repertoire selection made use of an unrelated antibody isomer with a wide, shallow binding site. Conformational diversity, whereby one sequence adopts multiple structures and multiple functions, can increase the effective size of the antibody repertoire but may also lead to autoimmunity and allergy.

About this Structure

1OAU is a Single protein structure of sequence from Rattus rattus. Full crystallographic information is available from OCA.

Reference

Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298

Page seeded by OCA on Thu Mar 20 13:08:14 2008

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