4gli
From Proteopedia
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| - | [[ | + | ==Crystal Structure of Human SMN YG-Dimer== |
| + | <StructureSection load='4gli' size='340' side='right' caption='[[4gli]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gli]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GLI FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994, SMN, SMN1, SMN2, SMNC, SMNT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gli OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gli RCSB], [http://www.ebi.ac.uk/pdbsum/4gli PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The survival motor neuron (SMN) protein forms the oligomeric core of a multiprotein complex that functions in spliceosomal snRNP biogenesis. Loss of function mutations in the SMN gene cause spinal muscular atrophy (SMA), a leading genetic cause of infant mortality. Nearly half of the known SMA patient missense mutations map to the SMN YG-box, a highly conserved oligomerization domain of unknown structure that contains a (YxxG)(3) motif. Here, we report that the SMN YG-box forms helical oligomers similar to the glycine zippers found in transmembrane channel proteins. A network of tyrosine-glycine packing between helices drives formation of soluble YG-box oligomers, providing a structural basis for understanding SMN oligomerization and for relating defects in oligomerization to the mutations found in SMA patients. These results have important implications for advancing our understanding of SMN function and glycine zipper-mediated helix-helix interactions. | ||
| - | + | The Survival Motor Neuron Protein Forms Soluble Glycine Zipper Oligomers.,Martin R, Gupta K, Ninan NS, Perry K, Van Duyne GD Structure. 2012 Sep 25. pii: S0969-2126(12)00327-9. doi:, 10.1016/j.str.2012.08.024. PMID:23022347<ref>PMID:23022347</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Duyne, G D.Van | + | [[Category: Duyne, G D.Van]] |
| - | [[Category: Martin, R S | + | [[Category: Martin, R S]] |
| - | [[Category: Perry, K | + | [[Category: Perry, K]] |
[[Category: Soluble glycine zipper]] | [[Category: Soluble glycine zipper]] | ||
[[Category: Splicing]] | [[Category: Splicing]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 09:20, 10 December 2014
Crystal Structure of Human SMN YG-Dimer
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