1ob4

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[[Image:1ob4.jpg|left|200px]]<br /><applet load="1ob4" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ob4.jpg|left|200px]]
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caption="1ob4, resolution 0.95&Aring;" />
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'''CEPHAIBOL A'''<br />
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{{Structure
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|PDB= 1ob4 |SIZE=350|CAPTION= <scene name='initialview01'>1ob4</scene>, resolution 0.95&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> and <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CEPHAIBOL A'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1OB4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Acremonium_tubakii Acremonium tubakii] with <scene name='pdbligand=ACE:'>ACE</scene> and <scene name='pdbligand=EOH:'>EOH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB4 OCA].
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1OB4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Acremonium_tubakii Acremonium tubakii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB4 OCA].
==Reference==
==Reference==
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Crystal structures of cephaibols., Bunkoczi G, Schiell M, Vertesy L, Sheldrick GM, J Pept Sci. 2003 Nov-Dec;9(11-12):745-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14658793 14658793]
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Crystal structures of cephaibols., Bunkoczi G, Schiell M, Vertesy L, Sheldrick GM, J Pept Sci. 2003 Nov-Dec;9(11-12):745-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14658793 14658793]
[[Category: Acremonium tubakii]]
[[Category: Acremonium tubakii]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: peptaibol]]
[[Category: peptaibol]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:15:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:08:31 2008''

Revision as of 11:08, 20 March 2008

Image:1ob4.jpg


PDB ID 1ob4

Drag the structure with the mouse to rotate
, resolution 0.95Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CEPHAIBOL A


Overview

The crystal structures of the peptaibol antibiotics cephaibol A, cephaibol B and cephaibol C have been determined at ca. 0.9 A resolution. All three adopt a helical conformation with a sharp bend (of about 55 degrees) at the central hydroxyproline. All isovalines were found to possess the D configuration, superposition of all four models (there are two independent molecules in the cephaibol B structure) shows that the N-terminal helix is rigid and the C-terminus is flexible. There are differences in the hydrogen bonding patterns for the three structures that crystallize in different space groups despite relatively similar unit cell dimensions, but only in the case of cephaibol C does the packing emulate the formation of a membrane channel believed to be important for their biological function.

About this Structure

1OB4 is a Single protein structure of sequence from Acremonium tubakii. Full crystallographic information is available from OCA.

Reference

Crystal structures of cephaibols., Bunkoczi G, Schiell M, Vertesy L, Sheldrick GM, J Pept Sci. 2003 Nov-Dec;9(11-12):745-52. PMID:14658793

Page seeded by OCA on Thu Mar 20 13:08:31 2008

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