4gwq
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==Structure of the Mediator Head Module from S. cerevisiae in complex with the carboxy-terminal domain (CTD) of RNA Polymerase II Rpb1 subunit== |
| + | <StructureSection load='4gwq' size='340' side='right' caption='[[4gwq]], [[Resolution|resolution]] 4.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gwq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast], [http://en.wikipedia.org/wiki/Clostridium_acetobutylicum Clostridium acetobutylicum] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GWQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rj1|3rj1]], [[2hzm|2hzm]], [[2hzs|2hzs]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gwq RCSB], [http://www.ebi.ac.uk/pdbsum/4gwq PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for Mediator-CTD interaction for transcription. | ||
| - | + | Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II.,Robinson PJ, Bushnell DA, Trnka MJ, Burlingame AL, Kornberg RD Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):17931-5. doi:, 10.1073/pnas.1215241109. Epub 2012 Oct 15. PMID:23071300<ref>PMID:23071300</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Baker's yeast]] | ||
[[Category: Clostridium acetobutylicum]] | [[Category: Clostridium acetobutylicum]] | ||
[[Category: DNA-directed RNA polymerase]] | [[Category: DNA-directed RNA polymerase]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | + | [[Category: Burlingame, A L]] | |
| - | [[Category: Burlingame, A L | + | [[Category: Bushnell, D A]] |
| - | [[Category: Bushnell, D A | + | [[Category: Kornberg, R D]] |
| - | [[Category: Kornberg, R D | + | [[Category: Robinson, P J.J]] |
| - | [[Category: Robinson, P J.J | + | [[Category: Trnka, M J]] |
| - | [[Category: Trnka, M J | + | |
[[Category: Binding site]] | [[Category: Binding site]] | ||
[[Category: Mediator complex]] | [[Category: Mediator complex]] | ||
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[[Category: Protein subunit]] | [[Category: Protein subunit]] | ||
[[Category: Rna polymerase ii]] | [[Category: Rna polymerase ii]] | ||
| - | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Structure-activity relationship]] | [[Category: Structure-activity relationship]] | ||
[[Category: Tertiary]] | [[Category: Tertiary]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 09:26, 10 December 2014
Structure of the Mediator Head Module from S. cerevisiae in complex with the carboxy-terminal domain (CTD) of RNA Polymerase II Rpb1 subunit
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Categories: Baker's yeast | Clostridium acetobutylicum | DNA-directed RNA polymerase | Saccharomyces cerevisiae | Burlingame, A L | Bushnell, D A | Kornberg, R D | Robinson, P J.J | Trnka, M J | Binding site | Mediator complex | Model | Molecular | Phosphorylation | Protein structure | Protein subunit | Rna polymerase ii | Structure-activity relationship | Tertiary | Transcription
