4h6w

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[[Image:4h6w.png|left|200px]]
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==Structure of Prenylagaramide maturation protease PagA==
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<StructureSection load='4h6w' size='340' side='right' caption='[[4h6w]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4h6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Planktothrix_agardhii_nies-596 Planktothrix agardhii nies-596]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H6W FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h6v|4h6v]], [[4h6x|4h6x]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pagA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=443922 Planktothrix agardhii NIES-596])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h6w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h6w RCSB], [http://www.ebi.ac.uk/pdbsum/4h6w PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cyanobactins, a class of ribosomally encoded macrocylic natural products, are biosynthesized through the proteolytic processing and subsequent N-C macrocylization of ribosomal peptide precursors. Macrocylization occurs through a two-step process in which the first protease (PatA) removes the amino terminal flanking sequence from the precursor to yield a free N terminus of the precursor peptide, and the second protease (PatG) removes the C-terminal flanking sequence and then catalyzes the transamidation reaction to yield an N-C cyclized product. Here, we present the crystal structures of the protease domains of PatA and PatG from the patellamide cluster and of PagA from the prenylagaramide cluster. A comparative structural and biochemical analysis of the transamidating PatG protease reveals the presence of a unique structural element distinct from canonical subtilisin proteases, which may facilitate the N-C macrocylization of the peptide substrate.
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{{STRUCTURE_4h6w| PDB=4h6w | SCENE= }}
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Structures of cyanobactin maturation enzymes define a family of transamidating proteases.,Agarwal V, Pierce E, McIntosh J, Schmidt EW, Nair SK Chem Biol. 2012 Nov 21;19(11):1411-22. doi: 10.1016/j.chembiol.2012.09.012. PMID:23177196<ref>PMID:23177196</ref>
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===Structure of Prenylagaramide maturation protease PagA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_23177196}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4h6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Planktothrix_agardhii_nies-596 Planktothrix agardhii nies-596]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H6W OCA].
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</StructureSection>
[[Category: Planktothrix agardhii nies-596]]
[[Category: Planktothrix agardhii nies-596]]
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[[Category: Agarwal, V.]]
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[[Category: Agarwal, V]]
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[[Category: Nair, S K.]]
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[[Category: Nair, S K]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Protease]]
[[Category: Protease]]

Revision as of 09:36, 10 December 2014

Structure of Prenylagaramide maturation protease PagA

4h6w, resolution 2.45Å

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