4hgw

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[[Image:4hgw.png|left|200px]]
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==Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide==
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<StructureSection load='4hgw' size='340' side='right' caption='[[4hgw]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [http://www.ebi.ac.uk/pdbsum/4hgw PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The near-germline antibody S25-2 exhibits a remarkable cross-reactivity for oligosaccharides containing the bacterial lipopolysaccharide carbohydrate 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo). The recent synthesis of a variety of Kdo analogues permits a detailed structural analysis of the importance of specific interactions in antigen recognition by S25-2. The Kdo disaccharide analogue Kdo-(2--&gt;4)-5,6-dehydro-Kdo lacks a 5-OH group on the second Kdo residue and has been cocrystallized with S25-2. The structure reveals that the modification of the Kdo residue at position 5 results in a rearrangement of intramolecular hydrogen bonds in the antigen that allows it to assume a novel conformation in the antibody-combining site. The cross-reactive binding of S25-2 to this synthetic ligand highlights the adaptability of this antibody to non-natural synthetic analogues.
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{{STRUCTURE_4hgw| PDB=4hgw | SCENE= }}
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Exploring the cross-reactivity of S25-2: complex with a 5,6-dehydro-Kdo disaccharide.,Brooks CL, Wimmer K, Kosma P, Muller-Loennies S, Brade L, Brade H, Evans SV Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):2-5. doi:, 10.1107/S1744309112047422. Epub 2012 Dec 25. PMID:23295476<ref>PMID:23295476</ref>
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===Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_23295476}}
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==See Also==
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*[[Antibody|Antibody]]
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==About this Structure==
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== References ==
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[[4hgw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Brooks, C L.]]
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[[Category: Brooks, C L]]
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[[Category: Evans, S V.]]
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[[Category: Evans, S V]]
[[Category: Antibody]]
[[Category: Antibody]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Lp]]
[[Category: Lp]]

Revision as of 09:40, 10 December 2014

Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide

4hgw, resolution 1.65Å

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