4gkz
From Proteopedia
(Difference between revisions)
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- | [[ | + | ==HA1.7, a MHC class II restricted TCR specific for haemagglutinin== |
+ | <StructureSection load='4gkz' size='340' side='right' caption='[[4gkz]], [[Resolution|resolution]] 2.39Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[4gkz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GKZ FirstGlance]. <br> | ||
+ | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gkz RCSB], [http://www.ebi.ac.uk/pdbsum/4gkz PDBsum]</span></td></tr> | ||
+ | </table> | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | Successful immunity requires that a limited pool of alphabeta T-cell receptors (TCRs) provide cover for a vast number of potential foreign peptide antigens presented by 'self' major histocompatibility complex (pMHC) molecules. Structures of unligated and ligated MHC class-I-restricted TCRs with different ligands, supplemented with biophysical analyses, have revealed a number of important mechanisms that govern TCR mediated antigen recognition. HA1.7 TCR binding to the influenza hemagglutinin antigen (HA(306-318)) presented by HLA-DR1 or HLA-DR4 represents an ideal system for interrogating pMHC-II antigen recognition. Accordingly, we solved the structure of the unligated HA1.7 TCR and compared it to both complex structures. Despite a relatively rigid binding mode, HA1.7 T-cells could tolerate mutations in key contact residues within the peptide epitope. Thermodynamic analysis revealed that limited plasticity and extreme favorable entropy underpinned the ability of the HA1.7 T-cell clone to cross-react with HA(306-318) presented by multiple MHC-II alleles. | ||
- | + | Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers.,Holland CJ, Rizkallah PJ, Vollers S, Calvo-Calle JM, Madura F, Fuller A, Sewell AK, Stern LJ, Godkin A, Cole DK Sci Rep. 2012;2:629. doi: 10.1038/srep00629. Epub 2012 Sep 4. PMID:22953050<ref>PMID:22953050</ref> | |
- | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
- | + | </div> | |
- | + | == References == | |
- | == | + | <references/> |
- | + | __TOC__ | |
+ | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
- | [[Category: Cole, D K | + | [[Category: Cole, D K]] |
- | [[Category: Godkin, A J | + | [[Category: Godkin, A J]] |
- | [[Category: Holland, C J | + | [[Category: Holland, C J]] |
- | [[Category: Rizkallah, P J | + | [[Category: Rizkallah, P J]] |
- | [[Category: Sewell, A K | + | [[Category: Sewell, A K]] |
[[Category: Ha1 7]] | [[Category: Ha1 7]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Influenza]] | [[Category: Influenza]] | ||
[[Category: T-cell]] | [[Category: T-cell]] |
Revision as of 09:41, 10 December 2014
HA1.7, a MHC class II restricted TCR specific for haemagglutinin
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Categories: Homo sapiens | Cole, D K | Godkin, A J | Holland, C J | Rizkallah, P J | Sewell, A K | Ha1 7 | Immune system | Influenza | T-cell