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4hru

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[[Image:4hru.png|left|200px]]
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==Molecular tweezers modulate 14-3-3 protein-protein interactions==
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<StructureSection load='4hru' size='340' side='right' caption='[[4hru]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HRU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19O:NATRIUM-(5,7+,9+,11+,16+,18+,20+,22+)-5,7,9,11,16,18,20,22-OCTAHYDRO-5,22 7,20 9,18 11,16-TETRAMETHANONONACEN-8,19-BISPHOSPHATE'>19O</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tol|3tol]], [[3tom|3tom]], [[3m51|3m51]], [[4fj3|4fj3]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HME1, NM_006142, SFN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hru RCSB], [http://www.ebi.ac.uk/pdbsum/4hru PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Supramolecular chemistry has recently emerged as a promising way to modulate protein functions, but devising molecules that will interact with a protein in the desired manner is difficult as many competing interactions exist in a biological environment (with solvents, salts or different sites for the target biomolecule). We now show that lysine-specific molecular tweezers bind to a 14-3-3 adapter protein and modulate its interaction with partner proteins. The tweezers inhibit binding between the 14-3-3 protein and two partner proteins-a phosphorylated (C-Raf) protein and an unphosphorylated one (ExoS)-in a concentration-dependent manner. Protein crystallography shows that this effect arises from the binding of the tweezers to a single surface-exposed lysine (Lys214) of the 14-3-3 protein in the proximity of its central channel, which normally binds the partner proteins. A combination of structural analysis and computer simulations provides rules for the tweezers' binding preferences, thus allowing us to predict their influence on this type of protein-protein interactions.
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{{STRUCTURE_4hru| PDB=4hru | SCENE= }}
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Molecular tweezers modulate 14-3-3 protein-protein interactions.,Bier D, Rose R, Bravo-Rodriguez K, Bartel M, Ramirez-Anguita JM, Dutt S, Wilch C, Klarner FG, Sanchez-Garcia E, Schrader T, Ottmann C Nat Chem. 2013 Mar;5(3):234-9. doi: 10.1038/nchem.1570. Epub 2013 Feb 17. PMID:23422566<ref>PMID:23422566</ref>
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===Molecular tweezers modulate 14-3-3 protein-protein interactions===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_23422566}}
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==See Also==
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*[[14-3-3 protein|14-3-3 protein]]
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==About this Structure==
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== References ==
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[[4hru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HRU OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bier, D.]]
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[[Category: Bier, D]]
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[[Category: Ottmann, C.]]
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[[Category: Ottmann, C]]
[[Category: 14-3-3]]
[[Category: 14-3-3]]
[[Category: Adaptor protein]]
[[Category: Adaptor protein]]
[[Category: Protein-protein interaction]]
[[Category: Protein-protein interaction]]
[[Category: Transferase inhibitor]]
[[Category: Transferase inhibitor]]

Revision as of 09:53, 10 December 2014

Molecular tweezers modulate 14-3-3 protein-protein interactions

4hru, resolution 3.15Å

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