1pfz
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1PFZ is a | + | 1PFZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Plasmepsin_II Plasmepsin II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39] Structure known Active Site: ASP. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PFZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: malaria]] | [[Category: malaria]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 12:27:51 2007'' |
Revision as of 10:22, 5 November 2007
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PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM
Overview
Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase, used by Plasmodiumfalciparum to digest hemoglobin during the blood stage, of malaria. A large shift between the N-domain and the central and, C-domains of proplasmepsin II opens the active site cleft, preventing the, formation of a functional aspartic proteinase active site. This mode of, inhibition of catalytic activity has not been observed in any other, aspartic proteinase zymogen. Instead of occluding a pre-formed active, site, as in the gastric aspartic proteinase zymogens, the prosegment of, proplasmepsin II interacts extensively with the C-domain and serves as a, 'harness' to keep the domains apart. Disruption of key salt bridges at low, pH may be important in activation.
About this Structure
1PFZ is a Single protein structure of sequence from Plasmodium falciparum with GOL as ligand. Active as Plasmepsin II, with EC number 3.4.23.39 Structure known Active Site: ASP. Full crystallographic information is available from OCA.
Reference
Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum., Bernstein NK, Cherney MM, Loetscher H, Ridley RG, James MN, Nat Struct Biol. 1999 Jan;6(1):32-7. PMID:9886289
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