Signal recognition particle protein

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'''Signal recognition particle''' (SRP) is a ribonucleoprotein which targets specific proteins to the endoplasmic reticulum (ER) in eukaryotes and the plasma membrane in prokaryotes. In eukaryotes SRP binds to the signal sequence of a newly synthesized polypeptide as it emerges from the ribosome. The binding allows for the coupling of the translation process to the translocation process. The SRP targets the nascent protein to the ER by docking into the [[Signal recognition particle receptor|SRP receptor]]. The eukaryotic SRP which has GTPase activity, is composed of SRP9, SRP14, SRP19, SRP54, SRP68, SRP72 and 7S RNA. The prokaryotic SRP is composed of FFH (SRP54-like) and 4.5S RNA.
'''Signal recognition particle''' (SRP) is a ribonucleoprotein which targets specific proteins to the endoplasmic reticulum (ER) in eukaryotes and the plasma membrane in prokaryotes. In eukaryotes SRP binds to the signal sequence of a newly synthesized polypeptide as it emerges from the ribosome. The binding allows for the coupling of the translation process to the translocation process. The SRP targets the nascent protein to the ER by docking into the [[Signal recognition particle receptor|SRP receptor]]. The eukaryotic SRP which has GTPase activity, is composed of SRP9, SRP14, SRP19, SRP54, SRP68, SRP72 and 7S RNA. The prokaryotic SRP is composed of FFH (SRP54-like) and 4.5S RNA.
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==3D structures of SRP==
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==3D structures of signal recognition particle==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===SRP===
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*Signal recognition particle
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[[1914]] – mSRP9/SRP14 – mouse<br />
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**[[1914]] – mSRP9/SRP14 – mouse<br />
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[[1wgw]] – mSRP54 N terminal – NMR<br />
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**[[1wgw]] – mSRP54 N terminal – NMR<br />
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[[1ls1]], [[2j45]], [[2j46]], [[1ffh]], [[1ng1]], [[3ng1]] - TaSRP54-like NG domain – ''Thermus aquaticus''<br />
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**[[1ls1]], [[2j45]], [[2j46]], [[1ffh]], [[1ng1]], [[3ng1]] - TaSRP54-like NG domain – ''Thermus aquaticus''<br />
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[[2ng1]] - TaSRP54-like NG domain (mutant)<br />
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**[[2ng1]] - TaSRP54-like NG domain (mutant)<br />
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[[2ffh]] - TaSRP54-like residues 1-425 (mutant)<br />
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**[[2ffh]] - TaSRP54-like residues 1-425 (mutant)<br />
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[[1kvn]], [[1kvv]] – SRP19 (mutant) – ''Archaeoglobus fulgidus'' – NMR<BR />
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**[[1kvn]], [[1kvv]] – SRP19 (mutant) – ''Archaeoglobus fulgidus'' – NMR<BR />
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[[1qb2]] – hSRP54 <br />
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**[[1qb2]] – hSRP54 <br />
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[[2hug]] – AtSRP43 chromo-2 domain + SRP54 M domain – ''Arabidopsis thaliana'' – NMR<BR />
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**[[2hug]] – AtSRP43 chromo-2 domain + SRP54 M domain – ''Arabidopsis thaliana'' – NMR<BR />
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[[3deo]] - AtSRP43 residues 85-267<br />
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**[[3deo]] - AtSRP43 residues 85-267<br />
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[[3ui2]] - AtSRP43 residues 84-327 + AtSRP54 RRKR motif<br />
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**[[3ui2]] - AtSRP43 residues 84-327 + AtSRP54 RRKR motif<br />
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[[3dlu]], [[3dlv]], [[3dm5]] – SRP19 – ''Pyrococcus furiosus''<br />
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**[[3dlu]], [[3dlv]], [[3dm5]] – SRP19 – ''Pyrococcus furiosus''<br />
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[[2w9j]] – SRP14 residues 1-91 – fission yeast<br />
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**[[2w9j]] – SRP14 residues 1-91 – fission yeast<br />
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[[1j8m]] – AaSPR GTPase domain – ''Acicianus ambivalens''<br />
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**[[1j8m]] – AaSPR GTPase domain – ''Acicianus ambivalens''<br />
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[[1j8y]] – AaSPR GTPase domain (mutant)<br />
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**[[1j8y]] – AaSPR GTPase domain (mutant)<br />
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[[1qzx]] – SsSRP54 – ''Sulfolobus solfataricus''<br />
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**[[1qzx]] – SsSRP54 – ''Sulfolobus solfataricus''<br />
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[[4p3f]] – hSRP68 (mutant) – human<br />
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**[[4p3f]] – hSRP68 (mutant) – human<br />
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*Signal recognition particle complexes with RNA
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===SRP complexes with RNA===
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**[[1e8o]], [[1e8s]] - hSRP9 + hSRP14 + 7S RNA <br />
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**[[1ry1]] - hSRP9 + hSRP14 + hSRP19 + hSRP54 + 7S RNA<br />
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**[[1jid]] – hSRP19 + RNA<br />
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**[[3ktv]] - hSRP19 + RNA S domain<br />
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**[[3ktw]] - SsSRP19 + RNA S domain <br />
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**[[1qzw]] – SsSRP + 7S RNA<br />
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**[[1lng]] – MjSRP19 + RNA – ''Methanocaldococcus jannaschii''<br />
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**[[1l9a]] - MjSRP19 (mutant) + RNA<br />
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**[[2v3c]], [[3ndb]] - MjSRP19 + MjSRP54 + 7S RNA<br />
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**[[1mfq]] – hSRP19 + hSRP54 M domain + 7S RNA S domain<br />
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**[[2iy3]] – TaSRP54-like + RNA - EM<BR />
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**[[1dul]], [[1hq1]], [[2pxp]] – EcSRP54-like C terminal + RNA – ''Escherichia coli''<br />
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**[[3lqx]] - EcSRP54-like + RNA + Co-hexamine<br />
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**[[2xkv]] - EcSRP54-like NG+M domains + 4.5SRNA – EM<BR />
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**[[2xxa]] - EcSRP54-like residues 1-433 (mutant) + cell division protein FtsY residues 196-497+ 4.5SRNA<br />
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**[[3zn8]] - EcSRP54 NG domain + cell division protein FtsY residues 201-495+ 4.5SRNA + dipeptidyl aminopeptidase B<br />
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**[[2pxb]], [[2pxd]], [[2pxe]], [[2pxf]], [[2pxk]], [[2pxl]], [[2pxq]], [[2pxq]], [[2pxt]], [[2pxu]], [[2pxv]] - EcSRP54-like C terminal + 4.5SRNA domain IV (mutant)<br />
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**[[2go5]] – dSRP19 + SRP54 + hSRP receptor α subunit + mSRP receptor b subunit + ribosomal proteins L23, L31, L35 + RNA – dog<br />
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**[[2j28]] – EcSRP54-like + 70S ribosome – EM<BR />
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**[[2j37]] - hSRP19 + dSRP54 + ribosomal proteins L23, L31, L35 + RNA – wheat – EM<BR />
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[[1e8o]], [[1e8s]] - hSRP9 + hSRP14 + 7S RNA <br />
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*Other signal recognition particle complexes
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[[1ry1]] - hSRP9 + hSRP14 + hSRP19 + hSRP54 + 7S RNA<br />
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[[1jid]] – hSRP19 + RNA<br />
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[[3ktv]] - hSRP19 + RNA S domain<br />
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[[3ktw]] - SsSRP19 + RNA S domain <br />
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[[1qzw]] – SsSRP + 7S RNA<br />
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[[1lng]] – MjSRP19 + RNA – ''Methanocaldococcus jannaschii''<br />
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[[1l9a]] - MjSRP19 (mutant) + RNA<br />
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[[2v3c]], [[3ndb]] - MjSRP19 + MjSRP54 + 7S RNA<br />
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[[1mfq]] – hSRP19 + hSRP54 M domain + 7S RNA S domain<br />
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[[2iy3]] – TaSRP54-like + RNA - EM<BR />
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[[1dul]], [[1hq1]], [[2pxp]] – EcSRP54-like C terminal + RNA – ''Escherichia coli''<br />
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[[3lqx]] - EcSRP54-like + RNA + Co-hexamine<br />
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[[2xkv]] - EcSRP54-like NG+M domains + 4.5SRNA – EM<BR />
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[[2xxa]] - EcSRP54-like residues 1-433 (mutant) + cell division protein FtsY residues 196-497+ 4.5SRNA<br />
+
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[[3zn8]] - EcSRP54 NG domain + cell division protein FtsY residues 201-495+ 4.5SRNA + dipeptidyl aminopeptidase B<br />
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[[2pxb]], [[2pxd]], [[2pxe]], [[2pxf]], [[2pxk]], [[2pxl]], [[2pxq]], [[2pxq]], [[2pxt]], [[2pxu]], [[2pxv]] - EcSRP54-like C terminal + 4.5SRNA domain IV (mutant)<br />
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[[2go5]] – dSRP19 + SRP54 + hSRP receptor α subunit + mSRP receptor b subunit + ribosomal proteins L23, L31, L35 + RNA – dog<br />
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[[2j28]] – EcSRP54-like + 70S ribosome – EM<BR />
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[[2j37]] - hSRP19 + dSRP54 + ribosomal proteins L23, L31, L35 + RNA – wheat – EM<BR />
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===Other SRP complexes===
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[[1jpj]], [[1jpn]], [[2c04]] – TaSRP54-like NG domain + GMPPNP<BR />
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[[1o87]], [[2c03]] - TaSRP54-like NG domain + GDP<br />
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[[1okk]], [[1rj9]], [[2cnw]] - TaSRP54-like NG domain + cell division protein FTSY<br />
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[[2j7p]] - TaSRP54-like NG domain + cell division protein FTSY + GMPPNP<BR />
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[[3dep]] - AtSRP43 residues 85-267 + polypeptide<br />
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[[3kl4]] – SsSRP54 residues 2-432 + polypeptide<br />
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[[4c7o]] – EcSRP + FTSY + SRP RNA<br />
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**[[1jpj]], [[1jpn]], [[2c04]] – TaSRP54-like NG domain + GMPPNP<BR />
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**[[1o87]], [[2c03]] - TaSRP54-like NG domain + GDP<br />
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**[[1okk]], [[1rj9]], [[2cnw]] - TaSRP54-like NG domain + cell division protein FTSY<br />
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**[[2j7p]] - TaSRP54-like NG domain + cell division protein FTSY + GMPPNP<BR />
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**[[3dep]] - AtSRP43 residues 85-267 + polypeptide<br />
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**[[3kl4]] – SsSRP54 residues 2-432 + polypeptide<br />
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**[[4c7o]] – EcSRP + FTSY + SRP RNA<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:27, 10 December 2014

Template:STRUCTURE 1e8o

Signal recognition particle (SRP) is a ribonucleoprotein which targets specific proteins to the endoplasmic reticulum (ER) in eukaryotes and the plasma membrane in prokaryotes. In eukaryotes SRP binds to the signal sequence of a newly synthesized polypeptide as it emerges from the ribosome. The binding allows for the coupling of the translation process to the translocation process. The SRP targets the nascent protein to the ER by docking into the SRP receptor. The eukaryotic SRP which has GTPase activity, is composed of SRP9, SRP14, SRP19, SRP54, SRP68, SRP72 and 7S RNA. The prokaryotic SRP is composed of FFH (SRP54-like) and 4.5S RNA.

3D structures of signal recognition particle

Updated on 10-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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