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Stimulator of interferon genes

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'''Stimulator of interferon genes''' (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites. STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses. The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP. STING is a facilitator of innate immune signaling.
'''Stimulator of interferon genes''' (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites. STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses. The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP. STING is a facilitator of innate immune signaling.
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</StructureSection>
==3D structures of STING==
==3D structures of STING==
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(Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Stimulator of interferon genes
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[[4ef5]], [[4f5w]], [[4f9e]] – hSTING CTD - human<br />
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**[[4ef5]], [[4f5w]], [[4f9e]] – hSTING CTD - human<br />
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[[4f5e]] – hSTING CTD (mutant) <br />
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**[[4f5e]] – hSTING CTD (mutant) <br />
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[[4jc5]], [[4kc0]] – mSTING CTD - mouse <br />
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**[[4jc5]], [[4kc0]] – mSTING CTD - mouse <br />
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===STING complex with ligand===
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*Stimulator of interferon genes complex with ligand
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[[4ef4]], [[4f5y]], [[4f9g]] – hSTING CTD + c-di-GMP <br />
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[[4emt]] – hSTING residues 155-341 + c-di-GMP <br />
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[[4f5d]] – hSTING CTD (mutant) + c-di-GMP <br />
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[[4kby]] – mSTING CTD + c-di-GMP <br />
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[[4ksy]] – hSTING CTD + cGAMP <br />
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[[4loh]], [[4loi]] – hSTING CTD + c-di-GMP derivative<br />
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[[4loj]], [[4lok]] – mSTING CTD + c-di-GMP derivative<br />
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[[4lol]] – mSTING CTD + chemptherapeutic agent DMXAA<br />
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**[[4ef4]], [[4f5y]], [[4f9g]] – hSTING CTD + c-di-GMP <br />
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**[[4emt]] – hSTING residues 155-341 + c-di-GMP <br />
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**[[4f5d]] – hSTING CTD (mutant) + c-di-GMP <br />
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**[[4kby]] – mSTING CTD + c-di-GMP <br />
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**[[4ksy]] – hSTING CTD + cGAMP <br />
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**[[4loh]], [[4loi]] – hSTING CTD + c-di-GMP derivative<br />
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**[[4loj]], [[4lok]] – mSTING CTD + c-di-GMP derivative<br />
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**[[4lol]] – mSTING CTD + chemptherapeutic agent DMXAA<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:15, 10 December 2014

Structure of human STING CTD complex with c-di-GMP (stick model) and Ca+2 ion (green) (PDB entry 4ef4)

Drag the structure with the mouse to rotate

3D structures of STING

(Updated on 10-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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