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2wh1

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==INSIGHTS INTO TRANSLATIONAL TERMINATION FROM THE STRUCTURE OF RF2 BOUND TO THE RIBOSOME==
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#REDIRECT [[4v5e]] This PDB entry is obsolete and replaced by 4v5e
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<StructureSection load='2wh1' size='340' side='right' caption='[[2wh1]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wh1]] is a 25 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jl5 2jl5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WH1 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wh2|2wh2]], [[2wh3|2wh3]], [[2wh4|2wh4]], [[1hr0|1hr0]], [[2v48|2v48]], [[1ibk|1ibk]], [[2b64|2b64]], [[1xmq|1xmq]], [[1ibl|1ibl]], [[2b9m|2b9m]], [[2uuc|2uuc]], [[2wdk|2wdk]], [[1pn8|1pn8]], [[2wdg|2wdg]], [[1xnr|1xnr]], [[1dv4|1dv4]], [[1hnz|1hnz]], [[1rss|1rss]], [[2wdh|2wdh]], [[2j02|2j02]], [[1j5e|1j5e]], [[1jgq|1jgq]], [[2j00|2j00]], [[2b9o|2b9o]], [[1i94|1i94]], [[1hnx|1hnx]], [[1i96|1i96]], [[2uu9|2uu9]], [[1pn7|1pn7]], [[2uub|2uub]], [[1vov|1vov]], [[1eg0|1eg0]], [[1ibm|1ibm]], [[1emi|1emi]], [[2uxb|2uxb]], [[2vqe|2vqe]], [[1g1x|1g1x]], [[1pnx|1pnx]], [[2v46|2v46]], [[2uua|2uua]], [[1i95|1i95]], [[1xnq|1xnq]], [[1qd7|1qd7]], [[2vqf|2vqf]], [[1gix|1gix]], [[1jgo|1jgo]], [[1jgp|1jgp]], [[1n32|1n32]], [[2f4v|2f4v]], [[1n34|1n34]], [[1n33|1n33]], [[1twt|1twt]], [[1pns|1pns]], [[1qzc|1qzc]], [[2uxd|2uxd]], [[1fka|1fka]], [[1yl4|1yl4]], [[2wdm|2wdm]], [[2uxc|2uxc]], [[1n36|1n36]], [[1fjg|1fjg]], [[1xmo|1xmo]], [[1hnw|1hnw]], [[1i97|1i97]], [[1l1u|1l1u]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wh1 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/2wh1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The termination of protein synthesis occurs through the specific recognition of a stop codon in the A site of the ribosome by a release factor (RF), which then catalyzes the hydrolysis of the nascent protein chain from the P-site transfer RNA. Here we present, at a resolution of 3.5 angstroms, the crystal structure of RF2 in complex with its cognate UGA stop codon in the 70S ribosome. The structure provides insight into how RF2 specifically recognizes the stop codon; it also suggests a model for the role of a universally conserved GGQ motif in the catalysis of peptide release.
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Insights into translational termination from the structure of RF2 bound to the ribosome.,Weixlbaumer A, Jin H, Neubauer C, Voorhees RM, Petry S, Kelley AC, Ramakrishnan V Science. 2008 Nov 7;322(5903):953-6. PMID:18988853<ref>PMID:18988853</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[Kink-turn motif|Kink-turn motif]]
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*[[Ribosomal protein THX|Ribosomal protein THX]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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*[[User:Wayne Decatur/kink-turn motif|User:Wayne Decatur/kink-turn motif]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Thermus thermophilus]]
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[[Category: Jin, H.]]
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[[Category: Kelley, A C.]]
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[[Category: Neubauer, C.]]
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[[Category: Petry, S.]]
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[[Category: Ramakrishnan, V.]]
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[[Category: Voorhees, R M.]]
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[[Category: Weixlbaumer, A.]]
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[[Category: Metal-binding]]
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[[Category: Mrna]]
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[[Category: Protein biosynthesis]]
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[[Category: Rf2]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome]]
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[[Category: Rna-binding]]
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[[Category: Rrna-binding]]
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[[Category: Termination]]
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[[Category: Translation]]
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[[Category: Trna]]
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[[Category: Trna-binding]]
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[[Category: Zinc-finger]]
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Current revision

  1. REDIRECT 4v5e This PDB entry is obsolete and replaced by 4v5e

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