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| - | {{STRUCTURE_3j39| PDB=3j39 | SCENE= }}
| + | #REDIRECT [[4v6w]] This PDB entry is obsolete and replaced by 4v6w |
| - | ===Structure of the D. melanogaster 60S ribosomal proteins===
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| - | {{ABSTRACT_PUBMED_23636399}}
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| - | ==Function==
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| - | [[http://www.uniprot.org/uniprot/RL3_DROME RL3_DROME]] The L3 protein is a component of the large subunit of cytoplasmic ribosomes. [[http://www.uniprot.org/uniprot/RL7_DROME RL7_DROME]] Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). [[http://www.uniprot.org/uniprot/RL5_DROME RL5_DROME]] This protein binds 5S RNA (By similarity). [[http://www.uniprot.org/uniprot/RL11_DROME RL11_DROME]] Binds to 5S ribosomal RNA (By similarity). [[http://www.uniprot.org/uniprot/RL40_DROME RL40_DROME]] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). Ribosomal protein L40 is a component of the 60S subunit of the ribosome. [[http://www.uniprot.org/uniprot/RL371_DROME RL371_DROME]] Binds to the 23S rRNA (By similarity). | + | |
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| - | ==About this Structure==
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| - | [[3j39]] is a 45 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J39 OCA].
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| - | [[Category: Drosophila melanogaster]]
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| - | [[Category: Anger, A M.]]
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| - | [[Category: Armache, J P.]]
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| - | [[Category: Beckmann, R.]]
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| - | [[Category: Berninghausen, O.]]
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| - | [[Category: Habeck, M.]]
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| - | [[Category: Subklewe, M.]]
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| - | [[Category: Wilson, D N.]]
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| - | [[Category: 80]]
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| - | [[Category: Eukarya]]
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| - | [[Category: Eukaryotic]]
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| - | [[Category: Mass spectrometry]]
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| - | [[Category: Protein synthesis]]
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| - | [[Category: Ribosomal]]
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| - | [[Category: Ribosome]]
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| - | [[Category: Rna]]
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