4abr

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==COMPLEX OF SMPB, A TMRNA FRAGMENT AND EF-TU-GDP-KIRROMYCIN WITH THE 70S RIBOSOME==
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#REDIRECT [[4v8q]] This PDB entry is obsolete and replaced by 4v8q
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<StructureSection load='4abr' size='340' side='right' caption='[[4abr]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4abr]] is a 27 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ABR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ABR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=KIR:KIRROMYCIN'>KIR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4abs|4abs]], [[1j1h|1j1h]], [[1ibk|1ibk]], [[1ibl|1ibl]], [[2uuc|2uuc]], [[2wdk|2wdk]], [[2y0u|2y0u]], [[2j02|2j02]], [[1j5e|1j5e]], [[2wrq|2wrq]], [[2b9o|2b9o]], [[1hnx|1hnx]], [[2j00|2j00]], [[2x9t|2x9t]], [[2wh3|2wh3]], [[2uub|2uub]], [[1vov|1vov]], [[1wjx|1wjx]], [[1emi|1emi]], [[2xqd|2xqd]], [[1pnx|1pnx]], [[2v46|2v46]], [[2vqf|2vqf]], [[2y10|2y10]], [[2wh1|2wh1]], [[1n32|1n32]], [[2y18|2y18]], [[2y12|2y12]], [[2wrn|2wrn]], [[2f4v|2f4v]], [[1twt|1twt]], [[1qzc|1qzc]], [[2uxd|2uxd]], [[1fka|1fka]], [[1fjg|1fjg]], [[1n36|1n36]], [[2uxc|2uxc]], [[1hnw|1hnw]], [[1l1u|1l1u]], [[1hr0|1hr0]], [[2v48|2v48]], [[2xuy|2xuy]], [[1xmq|1xmq]], [[2b64|2b64]], [[2b9m|2b9m]], [[1pn8|1pn8]], [[2wdg|2wdg]], [[1xnr|1xnr]], [[1dv4|1dv4]], [[1hnz|1hnz]], [[1rss|1rss]], [[2wdh|2wdh]], [[1jgq|1jgq]], [[1i94|1i94]], [[1i96|1i96]], [[2xsy|2xsy]], [[2uu9|2uu9]], [[1pn7|1pn7]], [[1eg0|1eg0]], [[1ibm|1ibm]], [[2uxb|2uxb]], [[3zzp|3zzp]], [[2vqe|2vqe]], [[1g1x|1g1x]], [[1ha3|1ha3]], [[1i95|1i95]], [[2uua|2uua]], [[1xnq|1xnq]], [[2xfz|2xfz]], [[1qd7|1qd7]], [[1gix|1gix]], [[1jgo|1jgo]], [[3zvo|3zvo]], [[1jgp|1jgp]], [[2xg1|2xg1]], [[2czj|2czj]], [[2c78|2c78]], [[2x9r|2x9r]], [[1n34|1n34]], [[1n33|1n33]], [[2y0w|2y0w]], [[1pns|1pns]], [[2jl7|2jl7]], [[1yl4|1yl4]], [[2y0y|2y0y]], [[2wdm|2wdm]], [[1xmo|1xmo]], [[1i97|1i97]], [[2y14|2y14]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4abr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4abr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4abr RCSB], [http://www.ebi.ac.uk/pdbsum/4abr PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In bacteria, ribosomes stalled at the end of truncated messages are rescued by transfer-messenger RNA (tmRNA), a bifunctional molecule that acts as both a transfer RNA (tRNA) and a messenger RNA (mRNA), and SmpB, a small protein that works in concert with tmRNA. Here, we present the crystal structure of a tmRNA fragment, SmpB and elongation factor Tu bound to the ribosome at 3.2 angstroms resolution. The structure shows how SmpB plays the role of both the anticodon loop of tRNA and portions of mRNA to facilitate decoding in the absence of an mRNA codon in the A site of the ribosome and explains why the tmRNA-SmpB system does not interfere with normal translation.
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Decoding in the absence of a codon by tmRNA and SmpB in the ribosome.,Neubauer C, Gillet R, Kelley AC, Ramakrishnan V Science. 2012 Mar 16;335(6074):1366-9. PMID:22422985<ref>PMID:22422985</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[Elongation factor|Elongation factor]]
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*[[Ribosomal protein THX|Ribosomal protein THX]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Thermus thermophilus]]
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[[Category: Gillet, R]]
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[[Category: Kelley, A C]]
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[[Category: Neubauer, C]]
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[[Category: Ramakrishnan, V]]
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[[Category: Ef-tu]]
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[[Category: Ribosome]]
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[[Category: Smpb]]
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[[Category: Tmrna]]
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Current revision

  1. REDIRECT 4v8q This PDB entry is obsolete and replaced by 4v8q

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