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4d1e
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2== |
| - | + | <StructureSection load='4d1e' size='340' side='right' caption='[[4d1e]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4d1e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D1E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d1e RCSB], [http://www.ebi.ac.uk/pdbsum/4d1e PDBsum]</span></td></tr> | |
| - | + | </table> | |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[http://omim.org/entry/612158 612158]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Djinovic-Carugo, K]] | ||
| + | [[Category: Gkougkoulia, E]] | ||
| + | [[Category: Pinotsis, N]] | ||
| + | [[Category: Salmazo, A]] | ||
| + | [[Category: Sjoeblom, B]] | ||
| + | [[Category: Abd]] | ||
| + | [[Category: Actin binding domain]] | ||
| + | [[Category: Calmodulin-like domain]] | ||
| + | [[Category: Contractile protein]] | ||
| + | [[Category: Spectrin domain]] | ||
| + | [[Category: Z-disc]] | ||
Revision as of 16:19, 10 December 2014
THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2
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