Thioesterase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 29: Line 29:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
===Maristoyl-ACP-specific TE===
+
*Maristoyl-ACP-specific thioesterase
-
[[1tht]] – TE – Vibrio harveyi
+
**[[1tht]] – TE – Vibrio harveyi
-
===4-hydroxybenzoyl-CoA TE===
+
*4-hydroxybenzoyl-CoA thioesterase
-
[[1bvq]] – PsTE – ''Pseudomonas''<br />
+
**[[1bvq]] – PsTE – ''Pseudomonas''<br />
-
[[1lo7]] – PsTE + 4-hydroxyphenyl CoA<br />
+
**[[1lo7]] – PsTE + 4-hydroxyphenyl CoA<br />
-
[[1lo9]] - PsTE (mutant) + 4-hydroxybenzoyl CoA<br />
+
**[[1lo9]] - PsTE (mutant) + 4-hydroxybenzoyl CoA<br />
-
[[1lo8]] - PsTE + 4-hydroxybenzyl CoA<br />
+
**[[1lo8]] - PsTE + 4-hydroxybenzyl CoA<br />
-
[[1q4s]] - ArTE + 4-hydroxybenzoate – '''Arthrobacte''r'<br />
+
**[[1q4s]] - ArTE + 4-hydroxybenzoate – '''Arthrobacte''r'<br />
-
[[1q4t]] - ArTE + 4-hydroxyphenyl CoA<br />
+
**[[1q4t]] - ArTE + 4-hydroxyphenyl CoA<br />
-
[[1q4u]] - ArTE + 4-hydroxybenzyl CoA<br />
+
**[[1q4u]] - ArTE + 4-hydroxybenzyl CoA<br />
-
[[3r32]], [[3r35]], [[3r37]], [[3r38]], [[3r3b]], [[3r3c]], [[3r3d]], [[3r3f]], [[3tea]] - ArTE (mutant) + 4-hydroxyphenacyl CoA<br />
+
**[[3r32]], [[3r35]], [[3r37]], [[3r38]], [[3r3b]], [[3r3c]], [[3r3d]], [[3r3f]], [[3tea]] - ArTE (mutant) + 4-hydroxyphenacyl CoA<br />
-
[[3r36]] - ArTE (mutant) + 4-hydroxybenzoate<br />
+
**[[3r36]] - ArTE (mutant) + 4-hydroxybenzoate<br />
-
[[3r3a]] - ArTE (mutant) + 4-hydroxybenzoate + CoA<br />
+
**[[3r3a]] - ArTE (mutant) + 4-hydroxybenzoate + CoA<br />
-
[[3r34]] - ArTE (mutant) + CoA<br />
+
**[[3r34]] - ArTE (mutant) + CoA<br />
-
===Palmitoyl protein TE===
+
*Palmitoyl protein thioesterase
-
[[1eh5]] – bTE1 + Palmitate – bovine<br />
+
**[[1eh5]] – bTE1 + Palmitate – bovine<br />
-
[[1ei9]] – bTE1<br />
+
**[[1ei9]] – bTE1<br />
-
[[1exw]] – bTE1 + hexadecylsulfonyl fluoride<br />
+
**[[1exw]] – bTE1 + hexadecylsulfonyl fluoride<br />
-
[[1pja]] – hTEII – human<br />
+
**[[1pja]] – hTEII – human<br />
-
[[3gro]] - hTEI
+
**[[3gro]] - hTEI
-
===Acyl-CoA TE===
+
*Acyl-CoA thioesterase
-
[[1c8u]] – EcTEII – ''Escherichia coli''<br />
+
**[[1c8u]] – EcTEII – ''Escherichia coli''<br />
-
[[1ivn]] – EcTEI<br />
+
**[[1ivn]] – EcTEI<br />
-
[[1jrl]] – EcTEI (mutant) <br />
+
**[[1jrl]] – EcTEI (mutant) <br />
-
[[1j00]] – EcTEI + diethyl phosphono derivative<br />
+
**[[1j00]] – EcTEI + diethyl phosphono derivative<br />
-
[[1v2g]], [[1u8u]] - EcTEI + octanoic acid<br />
+
**[[1v2g]], [[1u8u]] - EcTEI + octanoic acid<br />
-
[[2v1o]] – mTE7 hotdog domain – mouse<br />
+
**[[2v1o]] – mTE7 hotdog domain – mouse<br />
-
[[2q2b]] – mTE7 C terminal<br />
+
**[[2q2b]] – mTE7 C terminal<br />
-
[[3hlk]] – hTE2<br />
+
**[[3hlk]] – hTE2<br />
-
[[3k2i]] – hTE4<br />
+
**[[3k2i]] – hTE4<br />
-
[[2qq2]] - hTE7 C terminal<br />
+
**[[2qq2]] - hTE7 C terminal<br />
-
[[3fo5]] – hTE11 START domain<br />
+
**[[3fo5]] – hTE11 START domain<br />
-
[[3b7k]] – hTE12<br />
+
**[[3b7k]] – hTE12<br />
-
[[3rd7]] – TE – ''Mycobacterium avium''<br />
+
**[[3rd7]] – TE – ''Mycobacterium avium''<br />
-
[[3u0a]] – TEII – ''Mycobacterium marinum''<br />
+
**[[3u0a]] – TEII – ''Mycobacterium marinum''<br />
-
[[1tbu]] – TE N terminal (peroximal) – yeast
+
**[[1tbu]] – TE N terminal (peroximal) – yeast
-
===Acyl protein TE===
+
*Acyl protein thioesterase
-
[[1fj2]] – EcTEI
+
**[[1fj2]] – EcTEI
-
===Acyl-ACP TE===
+
*Acyl-ACP thioesterase
-
[[2ess]] – TE – ''Bacterioides thetaiotaomicron''<br />
+
**[[2ess]] – TE – ''Bacterioides thetaiotaomicron''<br />
-
[[4gak]] – TE – ''Spirosoma linguale''<br />
+
**[[4gak]] – TE – ''Spirosoma linguale''<br />
-
[[4gwh]] – TE – ''Yersinia pestis''<br />
+
**[[4gwh]] – TE – ''Yersinia pestis''<br />
-
===ACP-polyene TE===
+
*ACP-polyene thioesterase
-
[[4i4j]] – TE – ''Streptomyces globisporus''<br />
+
**[[4i4j]] – TE – ''Streptomyces globisporus''<br />
-
===Fluoroacetyl-CoA TE===
+
*Fluoroacetyl-CoA thioesterase
-
[[3kuv]], [[3kuw]], [[3kvi]] – ScTE (mutant) + acetate derivative – ''Streptomyces cattleya''<br />
+
**[[3kuv]], [[3kuw]], [[3kvi]] – ScTE (mutant) + acetate derivative – ''Streptomyces cattleya''<br />
-
[[3kv7]], [[3kv8]], [[3p2r]], [[3p2s]] – ScTE + acetate derivative<br />
+
**[[3kv7]], [[3kv8]], [[3p2r]], [[3p2s]] – ScTE + acetate derivative<br />
-
[[3kvu]] – ScTE + acetyl-CoA<br />
+
**[[3kvu]] – ScTE + acetyl-CoA<br />
-
[[3kvz]], [[3kw1]] – ScTE + FAcOPan<br />
+
**[[3kvz]], [[3kw1]] – ScTE + FAcOPan<br />
-
[[3kx7]], [[3kx8]], [[3p2q]] – ScTE <br />
+
**[[3kx7]], [[3kx8]], [[3p2q]] – ScTE <br />
-
[[3p3f]] – ScTE (mutant) <br />
+
**[[3p3f]] – ScTE (mutant) <br />
-
[[3p3i]] - ScTE (mutant) + acetate derivative + CoA<br />
+
**[[3p3i]] - ScTE (mutant) + acetate derivative + CoA<br />
-
===DHNA-CoA TE===
+
*Dihydroxynaphthoyl-CoA thioesterase
-
[[4k00]] – TE – ''Synechocystis''<br />
+
**[[4k00]] – TE – ''Synechocystis''<br />
-
[[4k02]] – TE – ''Arabidopsis thaliana''<br />
+
**[[4k02]] – TE – ''Arabidopsis thaliana''<br />
-
===Ubiquitin TE===
+
*Ubiquitin thioesterase
-
''USP 2''
+
*Ubiquitin thioesterase 2
-
[[2zfy]] – hUSP – human <BR />
+
**[[2zfy]] – hUSP – human <BR />
-
[[2hd5]], [[3nhe]], [[3v6c]], [[3v6e]] – hUSP + Ub <BR />
+
**[[2hd5]], [[3nhe]], [[3v6c]], [[3v6e]] – hUSP + Ub <BR />
-
[[1tff]] – hUSP (mutant) <BR />
+
**[[1tff]] – hUSP (mutant) <BR />
-
[[2ibi]] – hUSP (mutant) + Ub <BR />
+
**[[2ibi]] – hUSP (mutant) + Ub <BR />
-
''USP 3''
+
*Ubiquitin thioesterase 3
-
[[2qiy]] – yUSP + USP-associated protein – yeast <BR />
+
**[[2qiy]] – yUSP + USP-associated protein – yeast <BR />
-
''USP 4''
+
*Ubiquitin thioesterase 4
-
[[2y6e]] – hUSP catalytic domain <br />
+
**[[2y6e]] – hUSP catalytic domain <br />
-
[[3jyu]] – mUSP N terminal domain - mouse<br />
+
**[[3jyu]] – mUSP N terminal domain - mouse<br />
-
''USP 5''
+
*Ubiquitin thioesterase 5
-
[[2dag]] – hUSP UBA domain 1 - NMR<br />
+
**[[2dag]] – hUSP UBA domain 1 - NMR<br />
-
[[2dak]] – hUSP UBA domain 2 - NMR<br />
+
**[[2dak]] – hUSP UBA domain 2 - NMR<br />
-
[[2g43]] – hUSP zinc finger USP domain<br />
+
**[[2g43]] – hUSP zinc finger USP domain<br />
-
[[2g45]] – hUSP zinc finger USP domain + Ub<br />
+
**[[2g45]] – hUSP zinc finger USP domain + Ub<br />
-
[[3ihp]] – hUSP + Ub <BR />
+
**[[3ihp]] – hUSP + Ub <BR />
-
''USP 7''
+
*Ubiquitin thioesterase 7
-
[[2f1z]] – hUSP<br />
+
**[[2f1z]] – hUSP<br />
-
[[1nb8]], [[4m5w]], [[4m5x]] – hUSP catalytic domain <br />
+
**[[1nb8]], [[4m5w]], [[4m5x]] – hUSP catalytic domain <br />
-
[[2kvr]] – hUSP UBL domain - NMR<br />
+
**[[2kvr]] – hUSP UBL domain - NMR<br />
-
[[4pyz]] – hUSP UBL domains 1+2<br />
+
**[[4pyz]] – hUSP UBL domains 1+2<br />
-
[[1yze]], [[2f1w]] – hUSP N terminal domain <br />
+
**[[1yze]], [[2f1w]] – hUSP N terminal domain <br />
-
[[2ylm]] – hUSP C terminal domain <br />
+
**[[2ylm]] – hUSP C terminal domain <br />
-
[[2f1x]], [[2f1y]], [[2foj]], [[2foo]], [[2fop]] – hUSP N terminal domain/peptide <br />
+
**[[2f1x]], [[2f1y]], [[2foj]], [[2foo]], [[2fop]] – hUSP N terminal domain/peptide <br />
-
''USP 7 complexes''
+
*Ubiquitin thioesterase 7 complexes
-
[[1nbf]] – hUSP catalytic domain + Ub aldehyde<br />
+
**[[1nbf]] – hUSP catalytic domain + Ub aldehyde<br />
-
[[1yy6]] – hUSP N terminal domain + EBNA1 peptide<br />
+
**[[1yy6]] – hUSP N terminal domain + EBNA1 peptide<br />
-
[[2xxn]] – hUSP TRAF domain + VIRF-4 peptide<br />
+
**[[2xxn]] – hUSP TRAF domain + VIRF-4 peptide<br />
-
[[3mqr]] – hUSP TRAF domain + HDMX peptide<br />
+
**[[3mqr]] – hUSP TRAF domain + HDMX peptide<br />
-
[[3mqs]] – hUSP TRAF domain + HDM2 peptide<br />
+
**[[3mqs]] – hUSP TRAF domain + HDM2 peptide<br />
-
[[4jjq]] – hUSP TRAF domain + E2 peptide<br />
+
**[[4jjq]] – hUSP TRAF domain + E2 peptide<br />
-
[[4kg9]] – hUSP TRAF domain + MCM-BP peptide<br />
+
**[[4kg9]] – hUSP TRAF domain + MCM-BP peptide<br />
-
''USP 8''
+
*Ubiquitin thioesterase 8
-
[[1whb]] – hUSP rhodanase domain – human - NMR<br />
+
**[[1whb]] – hUSP rhodanase domain – human - NMR<br />
-
[[2a9u]] – hUSP N terminal domain <br />
+
**[[2a9u]] – hUSP N terminal domain <br />
-
[[2gfo]] – hUSP catalytic domain <br />
+
**[[2gfo]] – hUSP catalytic domain <br />
-
''USP 8 complexes''
+
*Ubiquitin thioesterase 8 complexes
-
[[2gwf]] – hUSP rhodanase domain + ring finger protein 41 USP8 interaction domain<br />
+
**[[2gwf]] – hUSP rhodanase domain + ring finger protein 41 USP8 interaction domain<br />
-
[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4f5k]], [[4fk5]] – yUSP + SUS1 + SGF11 +SGF73 <br />
+
**[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4f5k]], [[4fk5]] – yUSP + SUS1 + SGF11 +SGF73 <br />
-
[[3mhs]] – yUSP + SUS1 + SGF11 +SGF73 + Ub<br />
+
**[[3mhs]] – yUSP + SUS1 + SGF11 +SGF73 + Ub<br />
-
[[3n3k]] – hUSP catalytic domain + Ub<br />
+
**[[3n3k]] – hUSP catalytic domain + Ub<br />
-
''USP 11''
+
*Ubiquitin thioesterase 11
-
[[4mel]] – hUSP DUSP+UBL domains <br />
+
**[[4mel]] – hUSP DUSP+UBL domains <br />
-
[[4mem]] – rUSP DUSP+UBL domains - rat<br />
+
**[[4mem]] – rUSP DUSP+UBL domains - rat<br />
-
''USP 13''
+
*Ubiquitin thioesterase 13
-
[[2l80]] – hUSP zinc finger domain - NMR<br />
+
**[[2l80]] – hUSP zinc finger domain - NMR<br />
-
[[2lbc]] – hUSP UBA domain - NMR<br />
+
**[[2lbc]] – hUSP UBA domain - NMR<br />
-
''USP 14''
+
*Ubiquitin thioesterase 14
-
[[1wgg]] – mUSP N terminal domain - NMR<br />
+
**[[1wgg]] – mUSP N terminal domain - NMR<br />
-
[[2ayn]] – hUSP<br />
+
**[[2ayn]] – hUSP<br />
-
[[2ayo]] – hUSP + Ub aldehyde<br />
+
**[[2ayo]] – hUSP + Ub aldehyde<br />
-
''USP 15''
+
*Ubiquitin thioesterase 15
-
[[3lmn]] – hUSP DUSP domain <BR />
+
**[[3lmn]] – hUSP DUSP domain <BR />
-
[[3ppa]], [[3pv1]], [[3t9l]], [[4a3o]], [[4a3p]] – hUSP DUSP+UBL domains <br />
+
**[[3ppa]], [[3pv1]], [[3t9l]], [[4a3o]], [[4a3p]] – hUSP DUSP+UBL domains <br />
-
[[1w6v]] – hUSP DUSP domain - NMR<br />
+
**[[1w6v]] – hUSP DUSP domain - NMR<br />
-
''USP 16''
+
*Ubiquitin thioesterase 16
-
[[2i50]] – hUSP zinc finger domain - NMR <BR />
+
**[[2i50]] – hUSP zinc finger domain - NMR <BR />
-
''USP 21''
+
*Ubiquitin thioesterase 21
-
[[3i3t]], [[2y5b]] – hUSP + Ub <BR />
+
**[[3i3t]], [[2y5b]] – hUSP + Ub <BR />
-
[[3mtn]] – hUSP + Ub inhibitor <BR />
+
**[[3mtn]] – hUSP + Ub inhibitor <BR />
-
''USP25''
+
*Ubiquitin thioesterase 25
-
[[1vdl]] – mUSP catalytic domain <br />
+
**[[1vdl]] – mUSP catalytic domain <br />
-
''USP 28''
+
*Ubiquitin thioesterase 28
-
[[2lva]] – hUSP N terminal - NMR <BR />
+
**[[2lva]] – hUSP N terminal - NMR <BR />
-
''USP 33''
+
*Ubiquitin thioesterase 33
-
[[2uzg]] – hUSP zinc finger domain - NMR <BR />
+
**[[2uzg]] – hUSP zinc finger domain - NMR <BR />
-
''USP 37''
+
*Ubiquitin thioesterase 37
-
[[3ihr]] – hUSP (mutant) <BR />
+
**[[3ihr]] – hUSP (mutant) <BR />
-
[[3a7s]] – hUSP catalytic domain (mutant) <BR />
+
**[[3a7s]] – hUSP catalytic domain (mutant) <BR />
-
''USP Cyld''
+
*Ubiquitin thioesterase Cyld
-
[[2vhf]] – hUSP USP domain <BR />
+
**[[2vhf]] – hUSP USP domain <BR />
-
''USP L1''
+
*Ubiquitin thioesterase L1
-
[[2etl]] – hUSP-L1 <br />
+
**[[2etl]] – hUSP-L1 <br />
-
[[3irt]], [[4jkj]] – hUSP (mutant) <BR />
+
**[[3irt]], [[4jkj]] – hUSP (mutant) <BR />
-
[[2len]] – hUSP (mutant) - NMR<BR />
+
**[[2len]] – hUSP (mutant) - NMR<BR />
-
[[3ifw]], [[3kvf]], [[3kw5]] – hUSP (mutant) + Ub<BR />
+
**[[3ifw]], [[3kvf]], [[3kw5]] – hUSP (mutant) + Ub<BR />
-
[[4dm9]] – hUSP + peptide inhibitor<BR />
+
**[[4dm9]] – hUSP + peptide inhibitor<BR />
-
''USP L3''
+
*Ubiquitin thioesterase L3
-
[[1uch]] – hUSP-L3 <br />
+
**[[1uch]] – hUSP-L3 <br />
-
[[1xd3]] – hUSP-L3 + UBC<br />
+
**[[1xd3]] – hUSP-L3 + UBC<br />
-
[[2we6]] – PfUSP-L3 – ''Plasmodium falciparum''<br />
+
**[[2we6]] – PfUSP-L3 – ''Plasmodium falciparum''<br />
-
[[2wdt]] – PfUSP-L3 + Ub <br />
+
**[[2wdt]] – PfUSP-L3 + Ub <br />
-
''USP L5''
+
*Ubiquitin thioesterase L5
-
[[3ris]] – hUSP catalytic domain <BR />
+
**[[3ris]] – hUSP catalytic domain <BR />
-
[[3rii]], [[3a7s]] – hUSP catalytic domain (mutant) <BR />
+
**[[3rii]], [[3a7s]] – hUSP catalytic domain (mutant) <BR />
-
[[3tb3]] – hUSP UCH domain (mutant) <BR />
+
**[[3tb3]] – hUSP UCH domain (mutant) <BR />
-
[[3ihr]] – hUSP-L5 (mutant) <br />
+
**[[3ihr]] – hUSP-L5 (mutant) <br />
-
''USP ZranB1''
+
*Ubiquitin thioesterase ZranB1
-
[[3zrh]] – hUSP <BR />
+
**[[3zrh]] – hUSP <BR />
-
''USP OTUB1''
+
*Ubiquitin thioesterase OTUB1
-
[[3von]] – hUSP + E2 <BR />
+
**[[3von]] – hUSP + E2 <BR />
-
[[4ddg]], [[4ddi]] – hUSP + Ub<BR />
+
**[[4ddg]], [[4ddi]] – hUSP + Ub<BR />
-
[[4ddi]], [[4i6l]] – hUSP (mutant) + Ub<BR />
+
**[[4i6l]] – hUSP (mutant) + Ub<BR />
-
[[4dhz]] – hUSP + E2 + Ub<BR />
+
**[[4dhz]] – hUSP + E2 + Ub<BR />
-
[[4boq]] - hUSP OTU domain <BR />
+
**[[4boq]] - hUSP OTU domain <BR />
-
[[4boz]] - hUSP OTU domain (mutant) + Ub <BR />
+
**[[4boz]] - hUSP OTU domain (mutant) + Ub <BR />
-
[[4bos]] - hUSP OTU domain (mutant) + Ub + OTUD2 peptide<BR />
+
**[[4bos]] - hUSP OTU domain (mutant) + Ub + OTUD2 peptide<BR />
-
[[4fjv]] - hUSP OTUB2 + Ub <BR />
+
**[[4fjv]] - hUSP OTUB2 + Ub <BR />
-
[[4dhj]] – nUSP + E2 + Ub - nematode<BR />
+
**[[4dhj]] – nUSP + E2 + Ub - nematode<BR />
-
[[4dhi]] – nUSP + E2 <BR />
+
**[[4dhi]] – nUSP + E2 <BR />
-
[[2kzr]] – mUSP UBX-like domain – NMR<br />
+
**[[2kzr]] – mUSP UBX-like domain – NMR<br />
-
[[4kdi]], [[4kdl]] – yUSP UBX-like domain + transitional endoplasmic reticulum ATPase<br />
+
**[[4kdi]], [[4kdl]] – yUSP UBX-like domain + transitional endoplasmic reticulum ATPase<br />
-
[[3by4]], [[3c0r]] - yUSP OTU domain + Ub<BR />
+
**[[3by4]], [[3c0r]] - yUSP OTU domain + Ub<BR />
-
[[3znh]] – USP + Ub – Crimean-Congo hemorrhagic fever virus<BR />
+
*Ubiquitin thioesterase
-
===RedJ TE===
+
**[[3znh]] – USP OTU domain + Ub – Crimean-Congo hemorrhagic fever virus<BR />
-
[[3qmv]], [[3qmw]] – TE –'' Streptomyces coelicolor''
+
*RedJ thioesterase
-
===Orf6 TE===
+
**[[3qmv]], [[3qmw]] – TE –'' Streptomyces coelicolor''
-
[[4i45]] – TE – ''Photobacterium profundum''<br />
+
*Orf6 thioesterase
-
[[2av9]], [[2o5u]], [[2o6b]], [[2o6t]], [[2o6u]], [[3qy3]] – TE – ''Pseudomonas aeruginosa''
+
**[[4i45]] – TE – ''Photobacterium profundum''<br />
 +
*thioesterase
 +
 +
**[[2av9]], [[2o5u]], [[2o6b]], [[2o6t]], [[2o6u]], [[3qy3]] – TE – ''Pseudomonas aeruginosa''
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:24, 11 December 2014

Template:STRUCTURE 1u8u

Thioesterase (TE) catalyzes the break of an ester bond to produce acid and alcohol at a thiol group. TEs are substrate-specific.

  • Palmitoyl protein TE removes fatty acids like palmitate from modified cysteine residues during lysosomal degradation.
  • 4-hydroxybenzoyl-CoA TE converts 4-hydroxybenzoyl-CoA to 4-hydroxybenzoate and CoA.
  • Acyl-CoA TE hydrolyzes acyl-CoA to the fatty acid and CoA and is involved in lipid metabolism.
  • Fluoroacetyl-CoA TE from Streptomyces cattleya hydrolyzes fluoroacetyl-CoA thus preventing it from being metabolized to the lethal 4-hydroxy-trans-aconitate.
  • Ubiquitin TE or ubiquitin carboxyl-terminal hydrolase (USP) removes conjugated ubiquitin (Ub) from proteins thus regulating protein level by preventing their degradation. USP hydrolyze the peptide bond at the C-terminal glycine of ubiquitin (UB). The USPs are involved in the processing of poly-UB precursors and of ubiquinated proteins. USP contains catalytic domain surrounded several domains: Ub-like (UBL); Ub-associated (UBA); zinc finger-Ub-specific protease domain (UBP or DUSP); TRF homology domain.
  • USP-L1, USP25 hydrolyze C-terminal adducts of UB.
  • USP-L3 hydrolyze C-terminal adducts of UB and NEDD8.
  • USP5 cleaves multiubiquitin polymers.
  • USP6 has ATP-independent isopeptidase activity.
  • USP7, USP4, USP13, USP15 deubiquitinate several proteins.
  • USP8 removes conjugated ubiquitin from proteins thus preventing protein degradation. USP8 is involved in cell proliferation and is active in the M phase of proliferation.
  • USP11, USP14 are proteasome-associated.
  • USP16, USP21 deubiquitinate histone H2A.
  • USP28 deubiquitinates proteins of the DNA damage pathway.
  • USP33 regulates centrosome duplication.
  • USP37 deubiquitinates cyclin A.


3D structures of thioesterase

Updated on 11-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Thioesterase"
Personal tools