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Thymidine kinase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Thymidine kinase===
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*'''Thymidine kinase'''
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[[1e2h]] – HsvTK – Herpes simplex virus 1<BR />
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**[[1e2h]] – HsvTK – Herpes simplex virus 1<BR />
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[[3e2i]] – TK – ''Staphylococcus aureus''<BR />
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**[[3e2i]] – TK – ''Staphylococcus aureus''<BR />
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[[2qpo]] – TmTK – ''Thermotoga maritima''
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**[[2qpo]] – TmTK – ''Thermotoga maritima''
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===Thymidine kinase complex with reactants or products===
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*Thymidine kinase complex with reactants or products
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[[1e2i]] - HsvTK + hydroxypropyladenine<BR />
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**[[1e2i]] - HsvTK + hydroxypropyladenine<BR />
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[[1e2j]] - HsvTK (mutant) + THM<BR />
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**[[1e2j]] - HsvTK (mutant) + THM<BR />
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[[1kim]] - HsvTK + THM<BR />
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**[[1kim]] - HsvTK + THM<BR />
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[[1vtk]] - HsvTK + THMP + ADP<BR />
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**[[1vtk]] - HsvTK + THMP + ADP<BR />
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[[2vtk]] - HsvTK + THM + ADP<BR />
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**[[2vtk]] - HsvTK + THM + ADP<BR />
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[[3vtk]] - HsvTK + substrate analog + ADP<BR />
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**[[3vtk]] - HsvTK + substrate analog + ADP<BR />
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[[3f0t]], [[1of1]], [[4jby]], [[4jbx]], [[4ivr]], [[4ivq]], [[4ivp]] – HsvTK residues 45-376 + thymine derivative <BR />
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**[[3f0t]], [[1of1]], [[4jby]], [[4jbx]], [[4ivr]], [[4ivq]], [[4ivp]] – HsvTK residues 45-376 + thymine derivative <BR />
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[[3rdp]] - HsvTK residues 45-376 + pyrimidine derivative<br />
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**[[3rdp]] - HsvTK residues 45-376 + pyrimidine derivative<br />
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[[1qhi]], [[1ki3]], [[1ki5]], [[1ki2]], [[1ki4]] - HsvTK + inhibitor<BR />
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**[[1qhi]], [[1ki3]], [[1ki5]], [[1ki2]], [[1ki4]] - HsvTK + inhibitor<BR />
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[[1e2p]], [[1e2m]], [[1e2n]], [[1e2k]], [[1e2l]], [[1ki6]], [[1ki7]], [[1ki8]] – HsvTK + substrate analog<BR />
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**[[1e2p]], [[1e2m]], [[1e2n]], [[1e2k]], [[1e2l]], [[1ki6]], [[1ki7]], [[1ki8]] – HsvTK + substrate analog<BR />
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[[1osn]] – TK + inhibitor + ADP - Human Herpes virus 3<BR />
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**[[1osn]] – TK + inhibitor + ADP - Human Herpes virus 3<BR />
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[[1p6x]] – EhvTK + THM – Equine Herpes virus 4<BR />
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**[[1p6x]] – EhvTK + THM – Equine Herpes virus 4<BR />
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[[1p72]] - EhvTK + THM + ADP<BR />
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**[[1p72]] - EhvTK + THM + ADP<BR />
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[[2qqe]] – TmTK + THM<BR />
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**[[2qqe]] – TmTK + THM<BR />
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[[2qq0]]– TmTK + THM + ADP + THMP + ANP<BR />
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**[[2qq0]] – TmTK + THM + ADP + THMP + ANP<BR />
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[[2b8t]] - TK + THM – ''Ureaplasma parvum''<BR />
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**[[2b8t]] - TK + THM – ''Ureaplasma parvum''<BR />
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[[2j9r]] – TK + THM – ''Bacillus anthracis''<BR />
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**[[2j9r]] – TK + THM – ''Bacillus anthracis''<BR />
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[[1xx6]] – TK + ADP – ''Clostridium acetobutylicum''
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**[[1xx6]] – TK + ADP – ''Clostridium acetobutylicum''
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===Thymidine kinase complex with feed-back inhibitor===
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*Thymidine kinase complex with feed-back inhibitor
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[[2j87]] – TK + TTP – Vaccinia virus<BR />
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**[[2j87]] – TK + TTP – Vaccinia virus<BR />
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[[2uz3]] – TK (mutant) + TTP – ''Ureaplasma urealyticum''<BR />
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**[[2uz3]] – TK (mutant) + TTP – ''Ureaplasma urealyticum''<BR />
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[[2ja1]] – TK + TTP – ''Bacillus cereus''
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**[[2ja1]] – TK + TTP – ''Bacillus cereus''
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===Thymidine kinase complex with bisubstrate inhibitor===
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*Thymidine kinase complex with bisubstrate inhibitor
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[[1p7c]] – HsvTK + TP5A<BR />
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**[[1p7c]] – HsvTK + TP5A<BR />
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[[1p73]] - EhvTK + TP4A<BR />
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**[[1p73]] - EhvTK + TP4A<BR />
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[[1p75]] - EhvTK + TP5A<BR />
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**[[1p75]] - EhvTK + TP5A<BR />
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[[2orw]] – TmTK + TP4A<BR />
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**[[2orw]] – TmTK + TP4A<BR />
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[[2ki5]] – HsvTK + aciclovir
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**[[2ki5]] – HsvTK + aciclovir
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===Thymidine kinase 1===
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*'''Thymidine kinase 1'''
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[[1xbt]] - hTK1 residues 1-193 – human<BR />
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**[[1xbt]] - hTK1 residues 1-193 – human<BR />
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[[2wvj]] – hTK1 residues 1-193 (mutant) + TTP<BR />
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**[[2wvj]] – hTK1 residues 1-193 (mutant) + TTP<BR />
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[[2orv]] – hTK1 (mutant) + TP4A<BR />
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**[[2orv]] – hTK1 (mutant) + TP4A<BR />
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===Thymidine kinase 2===
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*'''Thymidine kinase 2'''
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[[1w4r]] – hTK2 + TTP
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**[[1w4r]] – hTK2 + TTP
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}}

Revision as of 06:52, 14 December 2014

Template:STRUCTURE 1e2j

Thymidine kinase (TK) catalyzes the conversion of deoxythymidine (THM) to deoxythymidine 5’-phosphate (THMP) with the coversion of ATP to ADP. TK has an important role in the synthesis of DNA. It is required for the action of many antiviral drugs. Higher organisms have 2 isozymes. TK1 is cell cycle-dependent while TK2 is found in the mitochondria and is cell cycle-independent. TK undergoes feed-back regulation by thymidine triphosphate (TTP). Adenosyl-thymidyl-tetraphosphate (TP4A) is a bisubstrate inhibitor of TK.

3D Structures of thymidine kinase

Updated on 14-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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