Thymidylate kinase

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===TMK===
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*Thymidylate kinase
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[[2cck]], [[4f4i]] – SaTMK – ''Staphylococcus aureus'' <br />
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**[[2cck]], [[4f4i]] – SaTMK – ''Staphylococcus aureus'' <br />
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[[2pbr]] – TMK – ''Aquifex aeolicus'' <br />
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**[[2pbr]] – TMK – ''Aquifex aeolicus'' <br />
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[[2plr]] – TMK – ''Sulfolobus tokodaii'' <br />
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**[[2plr]] – TMK – ''Sulfolobus tokodaii'' <br />
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[[3ld9]] – TMK – ''Ehrlichia chafeensis''<br />
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**[[3ld9]] – TMK – ''Ehrlichia chafeensis''<br />
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[[3v9p]] – TMK – ''Burkholderia thailandensis''<br />
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**[[3v9p]] – TMK – ''Burkholderia thailandensis''<br />
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[[3uwk]], [[3uwo]] – PaTMK – ''Pseudomonas aeruginosa''<br />
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**[[3uwk]], [[3uwo]] – PaTMK – ''Pseudomonas aeruginosa''<br />
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===TMK complex with HIV prodrug AZT derivative===
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*Thymidylate kinase complex with HIV prodrug AZT derivative
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[[2tmk]] – yTMK + AZTP <br />
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**[[2tmk]] – yTMK + AZTP <br />
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[[4eaq]] – SaTMK + AZTP <br />
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**[[4eaq]] – SaTMK + AZTP <br />
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[[4gmd]] – PaTMK + AZTP <br />
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**[[4gmd]] – PaTMK + AZTP <br />
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[[4tmk]], [[5tmp]] – TMK + AZTP – ''Escherichia coli''<br />
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**[[4tmk]], [[5tmp]] – TMK + AZTP – ''Escherichia coli''<br />
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[[1w2h]] – MtTMK + AZTP - ''Mycobacterium tuberculosis'' <br />
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**[[1w2h]] – MtTMK + AZTP - ''Mycobacterium tuberculosis'' <br />
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[[1e98]], [[1e99]], [[1e9d]] – hTMK (mutant) + AZTP + ADP<br />
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**[[1e98]], [[1e99]], [[1e9d]] – hTMK (mutant) + AZTP + ADP<br />
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===TMK complex with nucleotides===
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*Thymidylate kinase complex with nucleotides
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[[2v54]] – VvTMK + TDP – Vaccinia virus<br />
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**[[2v54]] – VvTMK + TDP – Vaccinia virus<br />
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[[2w0s]] – VvTMK + brivudin-MP <br />
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**[[2w0s]] – VvTMK + brivudin-MP <br />
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[[1tmk]] – yTMK + dTMP - yeast<br />
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**[[1tmk]] – yTMK + dTMP - yeast<br />
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[[4e5u]] – PaTMK + dTMP <br />
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**[[4e5u]] – PaTMK + dTMP <br />
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[[2ccg]], [[2ccj]], [[4dwj]] – SaTMK + dTMP <br />
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**[[2ccg]], [[2ccj]], [[4dwj]] – SaTMK + dTMP <br />
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[[1g3u]], [[1gsi]], [[1n5i]], [[1n5k]] – MtTMK + dTMP <br />
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**[[1g3u]], [[1gsi]], [[1n5i]], [[1n5k]] – MtTMK + dTMP <br />
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[[1w2g]] – MtTMK + thymidine <br />
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**[[1w2g]] – MtTMK + thymidine <br />
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[[1gtv]] – MtTMK + TDP <br />
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**[[1gtv]] – MtTMK + TDP <br />
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[[1n5j]] – MtTMK + TDP + TTP<br />
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**[[1n5j]] – MtTMK + TDP + TTP<br />
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[[1n5l]] – MtTMK + TDP + dTMP <br />
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**[[1n5l]] – MtTMK + TDP + dTMP <br />
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[[1mrs]] – MtTMK + UMP derivative <br />
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**[[1mrs]] – MtTMK + UMP derivative <br />
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[[3uxm]], [[4esh]] – PaTMK + deoxy thymidine derivative <br />
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**[[3uxm]], [[4esh]] – PaTMK + deoxy thymidine derivative <br />
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[[3hjn]] – TMK + ADP + TDP – ''Thermotoga maritima''<br />
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**[[3hjn]] – TMK + ADP + TDP – ''Thermotoga maritima''<br />
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[[1e2d]], [[1e2e]], [[1e2f]], [[1e9e]], [[1e9f]] – hTMK (mutant) + ADP + dTMP - human<br />
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**[[1e2d]], [[1e2e]], [[1e2f]], [[1e9e]], [[1e9f]] – hTMK (mutant) + ADP + dTMP - human<br />
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[[1e9f]] – hTMK (mutant) + ADP + dTMP - human<br />
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**[[1e9f]] – hTMK (mutant) + ADP + dTMP - human<br />
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[[4edh]] – PaTMK + ADP + dTMP <br />
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**[[4edh]] – PaTMK + ADP + dTMP <br />
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[[3lv8]] – VcTMK + ADP + dTMP + TDP – ''Vibrio cholerae''<br />
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**[[3lv8]] – VcTMK + ADP + dTMP + TDP – ''Vibrio cholerae''<br />
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[[3n2i]] – VcTMK + thymidine + thymidine deoxy-thymidine<br />
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**[[3n2i]] – VcTMK + thymidine + thymidine deoxy-thymidine<br />
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[[1e9b]] – hTMK (mutant) + azido-TMP + APPNP<br />
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**[[1e9b]] – hTMK (mutant) + azido-TMP + APPNP<br />
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[[1e9c]] – hTMK (mutant) + dTMP + APPNP<br />
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**[[1e9c]] – hTMK (mutant) + dTMP + APPNP<br />
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[[1nmx]] – hTMK (mutant) + F-TMP + ADP<br />
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**[[1nmx]] – hTMK (mutant) + F-TMP + ADP<br />
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[[1nmy]], [[1nn0]], [[1nnz]], [[1nn1]], [[1nn3]], [[1nn5]], [[1nmz]] – hTMK (mutant) + dTMP derivative + APPNP<br />
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**[[1nmy]], [[1nn0]], [[1nnz]], [[1nn1]], [[1nn3]], [[1nn5]], [[1nmz]] – hTMK (mutant) + dTMP derivative + APPNP<br />
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[[2xx3]] – hTMK + dTMP derivative + ADP<br />
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**[[2xx3]] – hTMK + dTMP derivative + ADP<br />
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[[2yof]], [[2yog]], [[2yoh]] - TMK + thymidine analog – ''Plasmodium falciparum''<br />
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**[[2yof]], [[2yog]], [[2yoh]] - TMK + thymidine analog – ''Plasmodium falciparum''<br />
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===Other TMK binary complexes===
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*Other thymidylate kinase binary complexes
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[[4gfd]], [[4hlc]], [[4hld]], [[4hej]], [[4hdc]] – SaTMK + antibacterial drug <br />
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**[[4gfd]], [[4hlc]], [[4hld]], [[4hej]], [[4hdc]] – SaTMK + antibacterial drug <br />
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[[4gsy]] – SaTMK + inhibitor<br />
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**[[4gsy]] – SaTMK + inhibitor<br />
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[[4mqb]] – SaTMK + MES<br />
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**[[4mqb]] – SaTMK + MES<br />
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===TMK complex with bisubstrate inhibitor===
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*Thymidylate kinase complex with bisubstrate inhibitor
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[[1mrn]] – MtTMK + TP5A <br />
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**[[1mrn]] – MtTMK + TP5A <br />
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[[3tmk]] – yTMK + TP5A <br />
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**[[3tmk]] – yTMK + TP5A <br />
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[[1e9a]] – hTMK (mutant) + azido-TP5A + ADP<br />
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**[[1e9a]] – hTMK (mutant) + azido-TP5A + ADP<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 13:01, 14 December 2014

Template:STRUCTURE 1e99

Thymidylate kinase (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. The TMK inhibitor azido-dTMP (AZTP) is an HIV AZT prodrug metabolite.

3D Structures of thymidylate kinase

Updated on 14-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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