Topoisomerase
From Proteopedia
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+ | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
- | + | *Topoisomerase I (ATP-independent) | |
- | [[3igc]], [[2h7f]], [[2h7g]] – TOPI+DNA – ''Smallpox virus''<br /> | + | **[[3igc]], [[2h7f]], [[2h7g]] – TOPI+DNA – ''Smallpox virus''<br /> |
- | [[2gai]], [[2gaj]] – TOPI – ''Thermotoga maritime''<br /> | + | **[[2gai]], [[2gaj]] – TOPI – ''Thermotoga maritime''<br /> |
- | [[2f4q]] – TOPIB – ''Deinococcus radiodurans''<br /> | + | **[[2f4q]] – TOPIB – ''Deinococcus radiodurans''<br /> |
- | [[1tl8]], [[1sc7]] – hTOPI+DNA+indenoisoquinoline – human<br /> | + | **[[1tl8]], [[1sc7]] – hTOPI+DNA+indenoisoquinoline – human<br /> |
- | [[1seu]] - hTOPI+DNA+indolocarbazole<br /> | + | **[[1seu]] - hTOPI+DNA+indolocarbazole<br /> |
- | [[1t8i]], [[1rr8]], [[1rrj]] - hTOPI+DNA+camptothesin<br /> | + | **[[1t8i]], [[1rr8]], [[1rrj]] - hTOPI+DNA+camptothesin<br /> |
- | [[1r49]] – hTOPI (mutant)<br /> | + | **[[1r49]] – hTOPI (mutant)<br /> |
- | [[1mw8]] – hTOPI (mutant) N-terminal+DNA<br /> | + | **[[1mw8]] – hTOPI (mutant) N-terminal+DNA<br /> |
- | [[1mw9]] - hTOPI (mutant) N-terminal<br /> | + | **[[1mw9]] - hTOPI (mutant) N-terminal<br /> |
- | [[1nh3]] – hTOPI C-terminal+DNA+Ara-C<br /> | + | **[[1nh3]] – hTOPI C-terminal+DNA+Ara-C<br /> |
- | [[1k4s]], [[1lpq]], [[1ej9]], [[1a31]], [[1a35]], [[1a36]] – hTOPI+DNA<br /> | + | **[[1k4s]], [[1lpq]], [[1ej9]], [[1a31]], [[1a35]], [[1a36]] – hTOPI+DNA<br /> |
- | [[1k4t]] - hTOPI+DNA+topotecan<br /> | + | **[[1k4t]] - hTOPI+DNA+topotecan<br /> |
- | [[1cy0]] – EcTOPI+DNA - ''Escherichia coli''<br /> | + | **[[1cy0]] – EcTOPI+DNA - ''Escherichia coli''<br /> |
- | [[3px7]] – EcTOPI (mutant) +DNA<br /> | + | **[[3px7]] – EcTOPI (mutant) +DNA<br /> |
- | [[1cy2]], [[1cy1]] – EcTOPI+5’TPTPTP3’<br /> | + | **[[1cy2]], [[1cy1]] – EcTOPI+5’TPTPTP3’<br /> |
- | [[1cy6]], [[1cy7]], [[1cy8]] – EcIOPI+TMP<br /> | + | **[[1cy6]], [[1cy7]], [[1cy8]] – EcIOPI+TMP<br /> |
- | [[1cy9]], [[1cyy]] – EcTOPI domain II+III<br /> | + | **[[1cy9]], [[1cyy]] – EcTOPI domain II+III<br /> |
- | [[1yua]] – EcTOPI C-terminal<br /> | + | **[[1yua]] – EcTOPI C-terminal<br /> |
- | [[1ecl]], [[1cy4]] - EcTOPI N-terminal<br /> | + | **[[1ecl]], [[1cy4]] - EcTOPI N-terminal<br /> |
- | [[3pwt]] - EcTOPIA N-terminal (mutant)<br /> | + | **[[3pwt]] - EcTOPIA N-terminal (mutant)<br /> |
- | [[1a41]] – VvTOPI C-terminal – ''Vaccinia virus''<br /> | + | **[[1a41]] – VvTOPI C-terminal – ''Vaccinia virus''<br /> |
- | [[1vcc]] – VvTOPI N-terminal<br /> | + | **[[1vcc]] – VvTOPI N-terminal<br /> |
- | [[1ois]] – yTOPI N-terminal - yeast<br /> | + | **[[1ois]] – yTOPI N-terminal - yeast<br /> |
- | + | *Topoisomerase I (ATP-dependent) – reverse gyrase | |
- | [[4ddt]], [[4ddu]], [[4ddv]], [[4ddw]], [[4ddx]] – TmTOPI <br /> | + | **[[4ddt]], [[4ddu]], [[4ddv]], [[4ddw]], [[4ddx]] – TmTOPI <br /> |
- | + | *Topoisomerase IIA | |
- | [[3l4j]] – yTOPII apo+DNA <br /> | + | **[[3l4j]] – yTOPII apo+DNA <br /> |
- | [[3l4k]] - yTOPII+DNA+Zn<br /> | + | **[[3l4k]] - yTOPII+DNA+Zn<br /> |
- | [[2rgr]] - yTOPIIA+DNA<br /> | + | **[[2rgr]] - yTOPIIA+DNA<br /> |
- | [[4gfh]] - yTOPIIA+DNA + ANPPNP<br /> | + | **[[4gfh]] - yTOPIIA+DNA + ANPPNP<br /> |
- | [[1qzr]] – yTOPII N-terminal+dexrazoxane<br /> | + | **[[1qzr]] – yTOPII N-terminal+dexrazoxane<br /> |
- | [[1pvg]] – yTOPII N-terminal<br /> | + | **[[1pvg]] – yTOPII N-terminal<br /> |
- | [[1bjt]], [[1bgw]] – yTOPII core<br /> | + | **[[1bjt]], [[1bgw]] – yTOPII core<br /> |
- | [[3ksa]], [[2ksb]] – SpTOPIIA+DNA – ''Streptococcus pneumoniae''<br /> | + | **[[3ksa]], [[2ksb]] – SpTOPIIA+DNA – ''Streptococcus pneumoniae''<br /> |
- | [[1zxm]] – hTOPIIA+AMP-PNP <br /> | + | **[[1zxm]] – hTOPIIA+AMP-PNP <br /> |
- | [[1zxn]] - hTOPIIA+ADP<br /> | + | **[[1zxn]] - hTOPIIA+ADP<br /> |
- | [[4fm9]] - hTOPIIA+DNA<br /> | + | **[[4fm9]] - hTOPIIA+DNA<br /> |
- | [[3kua]] – TOPII residues 362-493 + CCDB – ''Vibrio fischeri''<br /> | + | **[[3kua]] – TOPII residues 362-493 + CCDB – ''Vibrio fischeri''<br /> |
- | + | *Topoisomerase IIB topo VI | |
- | [[2zbk]] – SsTOPIIB subunit A+B – ''Sulfolobus shibatae''<br /> | + | **[[2zbk]] – SsTOPIIB subunit A+B – ''Sulfolobus shibatae''<br /> |
- | [[2hkj]], [[1mu5]], [[1mx0]] - SsTOPIIB subunit B<br /> | + | **[[2hkj]], [[1mu5]], [[1mx0]] - SsTOPIIB subunit B<br /> |
- | [[1z59]], [[1z5a]] - SsTOPIIB subunit B+ADP<br /> | + | **[[1z59]], [[1z5a]] - SsTOPIIB subunit B+ADP<br /> |
- | [[1z5b]] - SsTOPIIB subunit B+ADP+AlF4<br /> | + | **[[1z5b]] - SsTOPIIB subunit B+ADP+AlF4<br /> |
- | [[1z5c]] - SsTOPIIB subunit B+ADP+Pi<br /> | + | **[[1z5c]] - SsTOPIIB subunit B+ADP+Pi<br /> |
- | [[2q2e]] - TOPIIB subunit A+B – ''Methanosarcina mazei''<br /> | + | **[[2q2e]] - TOPIIB subunit A+B – ''Methanosarcina mazei''<br /> |
- | [[1d3y]] - TOPIIB subunit A - ''Methanocaldococcus janaschii''<br /> | + | **[[1d3y]] - TOPIIB subunit A - ''Methanocaldococcus janaschii''<br /> |
- | [[4j3n]] - hTOPIIB subunit A+B + DNA <br /> | + | **[[4j3n]] - hTOPIIB subunit A+B + DNA <br /> |
- | [[4g0w]], [[3qx3]], [[4g0v]], [[4g0u]] - hTOPIIB + DNA + anti-cancer drug<br /> | + | **[[4g0w]], [[3qx3]], [[4g0v]], [[4g0u]] - hTOPIIB + DNA + anti-cancer drug<br /> |
- | + | *Topoisomerase III | |
- | [[2o19]], [[2o54]], [[2o59]], [[2o5c]], [[2o5e]], [[1i7d]] – EcTOPIII+DNA <br /> | + | **[[2o19]], [[2o54]], [[2o59]], [[2o5c]], [[2o5e]], [[1i7d]] – EcTOPIII+DNA <br /> |
- | [[1d6m]] - EcTOPIII<br /> | + | **[[1d6m]] - EcTOPIII<br /> |
- | [[4cgy]], [[4cht]] – hTOPIIIα + RecQ-mediated genome instability protein<br /> | + | **[[4cgy]], [[4cht]] – hTOPIIIα + RecQ-mediated genome instability protein<br /> |
- | + | *Topoisomerase IV | |
- | [[3fv5]] – EcTOPIV subunit B <br /> | + | **[[3fv5]] – EcTOPIV subunit B <br /> |
- | [[4hz0]] - EcTOPIV subunit B + inhibitor<br /> | + | **[[4hz0]] - EcTOPIV subunit B + inhibitor<br /> |
- | [[1zvt]], [[1zvu]] - EcTOPIV subunit A<br /> | + | **[[1zvt]], [[1zvu]] - EcTOPIV subunit A<br /> |
- | [[4mn4]] - EcTOPIV subunit A + MukB<br /> | + | **[[4mn4]] - EcTOPIV subunit A + MukB<br /> |
- | [[1s14]] – EcTOPIV ParE<br /> | + | **[[1s14]] – EcTOPIV ParE<br /> |
- | [[1s16]] - EcTOPIV ParE+ADPNP<br /> | + | **[[1s16]] - EcTOPIV ParE+ADPNP<br /> |
- | [[3ltn]], [[3k9f]], [[3ksb]], [[3rad]], [[3rae]], [[3raf]], [[4i3h]], [[4juo]] - SpTOPIV subunit A+B+DNA<br /> | + | **[[3ltn]], [[3k9f]], [[3ksb]], [[3rad]], [[3rae]], [[3raf]], [[4i3h]], [[4juo]] - SpTOPIV subunit A+B+DNA<br /> |
- | [[3foe]], [[3fof]] - SpTOPIV subunit A+B+DNA+quinolone<br /> | + | **[[3foe]], [[3fof]] - SpTOPIV subunit A+B+DNA+quinolone<br /> |
- | [[2nov]] - SpTOPIV subunit A<br /> | + | **[[2nov]] - SpTOPIV subunit A<br /> |
- | [[4em7]], [[4emv]], [[4lp0]], [[4lpb]], [[4mb9]], [[4mbc]], [[4mot]] - SpTOPIV subunit B + inhibitor<br /> | + | **[[4em7]], [[4emv]], [[4lp0]], [[4lpb]], [[4mb9]], [[4mbc]], [[4mot]] - SpTOPIV subunit B + inhibitor<br /> |
- | [[2inr]] - TOPIV subunit A – ''Staphylococcus aureus''<br /> | + | **[[2inr]] - TOPIV subunit A – ''Staphylococcus aureus''<br /> |
- | [[1wp5]] – TOPIV C-terminal – ''Geobacillus stearothermophilus''<br /> | + | **[[1wp5]] – TOPIV C-terminal – ''Geobacillus stearothermophilus''<br /> |
- | [[2xkj]] – AbTOPIV pare+parc subunits – ''Acinetobacter baumannii''<br /> | + | **[[2xkj]] – AbTOPIV pare+parc subunits – ''Acinetobacter baumannii''<br /> |
- | [[2xkk]] - AbTOPIV pare+parc subunits+DNA<br /> | + | **[[2xkk]] - AbTOPIV pare+parc subunits+DNA<br /> |
- | [[3lnu]], [[3lps]] - TOPIV subunit B N-terminal – ''Xanthomonas oryzae''<br /> | + | **[[3lnu]], [[3lps]] - TOPIV subunit B N-terminal – ''Xanthomonas oryzae''<br /> |
- | [[4hxz]], [[4hy1]] - hTOPIV subunit B + inhibitor<br /> | + | **[[4hxz]], [[4hy1]] - hTOPIV subunit B + inhibitor<br /> |
- | [[4hym]], [[4kqv]] - TOPIV subunit B + inhibitor – ''Francisella tularensis''<br /> | + | **[[4hym]], [[4kqv]] - TOPIV subunit B + inhibitor – ''Francisella tularensis''<br /> |
- | [[4hz5]] - TOPIV subunit B + inhibitor – ''Enterococcus faecalis''<br /> | + | **[[4hz5]] - TOPIV subunit B + inhibitor – ''Enterococcus faecalis''<br /> |
- | + | *Topoisomerase V | |
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
+ | **[[2csb]], [[2csd]], [[4gfj]] – TOPV – ''Methanopyrus kandleri''<br /> | ||
+ | **[[3m6k]], [[3m7g]] – MkTOPV N-terminal<br /> | ||
+ | **[[3m6z]] - MkTOPV N-terminal+guanidine<br /> | ||
+ | **[[3m7d]] - MkTOPV N-terminal+dioxane | ||
+ | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
<br /> | <br /> | ||
Created with the participation of [[User:Sonny Zhao|Sonny Zhao]]. | Created with the participation of [[User:Sonny Zhao|Sonny Zhao]]. |
Revision as of 10:06, 15 December 2014
Image:2f4q.png
Crystal Structure of Topoisomerase 2f4q
Topoisomerase (TOP) winds and unwinds DNA double helix in order to enable DNA replication.
- TOPI cuts one strand of the double helix. It has 3 subclasses: TOPIA which shares its mechanism with TOPII and TOPIB which uses rotary mechanism and includes topo I and topo III. TOPIC called TOPV shares its mechanism with TOPIB but is structurally unique.
- TOPII cuts both strands of the double helix. Its subclasses are TOPIIA including topo II and TOPIIB which includes topo VI.
- TOPIV is a type of TOPII, contains an ATP-binding domain ParE and a catalytic domain ParC.
See also Variola Topoisomerase 1B.
Function
The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. TOP3 is a potent decatenase.
GO Annotations
Database | ID | Symbol | Qualifier | GO Identifier | GO Term Name | Aspect | Evidence | Reference | With | Taxon | Date | Assigned by | Product Form ID |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB | P14294 | topB | GO:0006259 | DNA metabolic process | P | IEA | InterPro2GO | InterPro:IPR006154 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR000380 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR003601 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR003602 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR005738 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR013497 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR013824 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR013825 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0006268 | DNA unwinding involved in replication | P | IEA | InterPro2GO | InterPro:IPR013824 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0006268 | DNA unwinding involved in replication | P | IEA | InterPro2GO | InterPro:IPR013825 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0000166 | nucleotide binding | F | IEA | Swiss-Prot Keywords2GO | SP_KW:KW-0547 | 83333 | 20101127 | UniProtKB | ||
UniProtKB | P14294 | topB | GO:0003676 | nucleic acid binding | F | IEA | InterPro2GO | InterPro:IPR006154 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR000380 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR003601 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR003602 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR005738 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR013497 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR013824 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR013825 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | Swiss-Prot Keywords2GO | SP_KW:KW-0238 | 83333 | 20101127 | UniProtKB | ||
UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR003601 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR003602 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR005738 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR013497 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR013824 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR013825 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | Swiss-Prot Keywords2GO | SP_KW:KW-0799 | 83333 | 20101127 | UniProtKB | ||
UniProtKB | P14294 | topB | GO:0003917 | DNA topoisomerase type I activity | F | IDA | PMID:6326814 | 83333 | 20100621 | EcoliWiki | |||
UniProtKB | P14294 | topB | GO:0003917 | DNA topoisomerase type I activity | F | IEA | InterPro2GO | InterPro:IPR000380 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0003917 | DNA topoisomerase type I activity | F | IEA | EC2GO | EC:5.99.1.2 | 83333 | 20100703 | UniProtKB | ||
UniProtKB | P14294 | topB | GO:0005515 | protein binding | F | IPI | PMID:15690043 | frlR (FRLR_ECOLI) | 83333 | 20101127 | IntAct | ||
UniProtKB | P14294 | topB | GO:0005524 | ATP binding | F | IEA | Swiss-Prot Keywords2GO | SP_KW:KW-0067 | 83333 | 20101127 | UniProtKB | ||
UniProtKB | P14294 | topB | GO:0016853 | isomerase activity | F | IEA | Swiss-Prot Keywords2GO | SP_KW:KW-0413 | 83333 | 20101127 | UniProtKB | ||
UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR000380 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR003601 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR003602 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR005738 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR013497 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR013824 | 83333 | 20101127 | InterPro | ||
UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR013825 | 83333 | 20101127 | InterPro |
Copied from [1] Last updated Dec 2 2010
3D Structures of Topoisomerase
Updated on 15-December-2014
Created with the participation of Sonny Zhao.
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, Alexander Berchansky, Jaime Prilusky