1oun
From Proteopedia
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| - | [[Image:1oun.jpg|left|200px]] | + | [[Image:1oun.jpg|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)''' | + | {{Structure |
| + | |PDB= 1oun |SIZE=350|CAPTION= <scene name='initialview01'>1oun</scene>, resolution 2.3Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OUN is a [ | + | 1OUN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OUN OCA]. |
==Reference== | ==Reference== | ||
| - | The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2)., Bullock TL, Clarkson WD, Kent HM, Stewart M, J Mol Biol. 1996 Jul 19;260(3):422-31. PMID:[http:// | + | The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2)., Bullock TL, Clarkson WD, Kent HM, Stewart M, J Mol Biol. 1996 Jul 19;260(3):422-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8757804 8757804] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:15:48 2008'' |
Revision as of 11:15, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)
Overview
Nuclear transport factor 2 (NTF2) facilitates protein transport into the nucleus and interacts with both the small Ras-like GTPase Ran and nucleoporin p62. We have determined the structure of bacterially expressed rat NTF2 at 1.6 angstroms resolution using X-ray crystallography. The NTF2 polypeptide chain forms an alpha + beta barrel that opens at one end to form a distinctive hydrophobic cavity and its fold is homologous to that of scytalone dehydratase. The NTF2 hydrophobic cavity is a candidate for a potential binding site for other proteins involved in nuclear import such as Ran and nucleoporin p62. In addition, the hydrophobic cavity contains a putative catalytic Asp-His pair, which raises the possibility of an unanticipated enzymatic activity of the molecule that may have implications for the molecular mechanism of nuclear protein import.
About this Structure
1OUN is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2)., Bullock TL, Clarkson WD, Kent HM, Stewart M, J Mol Biol. 1996 Jul 19;260(3):422-31. PMID:8757804
Page seeded by OCA on Thu Mar 20 13:15:48 2008
