3l46

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m (Protected "3l46" [edit=sysop:move=sysop])
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{{STRUCTURE_3l46| PDB=3l46 | SCENE= }}
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==Crystal structure of the second BRCT domain of epithelial cell transforming 2 (ECT2)==
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===Crystal structure of the second BRCT domain of epithelial cell transforming 2 (ECT2)===
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<StructureSection load='3l46' size='340' side='right' caption='[[3l46]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3l46]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L46 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/ECT2_HUMAN ECT2_HUMAN]] Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.<ref>PMID:10579713</ref> <ref>PMID:14645260</ref> <ref>PMID:15254234</ref> <ref>PMID:15545273</ref> <ref>PMID:15642749</ref> <ref>PMID:16103226</ref> <ref>PMID:16495035</ref> <ref>PMID:16236794</ref> <ref>PMID:16170345</ref> <ref>PMID:19129481</ref> <ref>PMID:19617897</ref> <ref>PMID:19468300</ref> <ref>PMID:21189248</ref> <ref>PMID:21373644</ref>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l46 RCSB], [http://www.ebi.ac.uk/pdbsum/3l46 PDBsum]</span></td></tr>
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[[3l46]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L46 OCA].
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</table>
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== Evolutionary Conservation ==
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==Reference==
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[[Image:Consurf_key_small.gif|200px|right]]
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<references group="xtra"/><references/>
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Check<jmol>
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[[Category: Homo sapiens]]
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<jmolCheckbox>
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[[Category: Arrowsmith, C H.]]
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l4/3l46_consurf.spt"</scriptWhenChecked>
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[[Category: Bochkarev, A.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Bountra, C.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Crombet, L.]]
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</jmolCheckbox>
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[[Category: Edwards, A M.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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[[Category: Guan, X.]]
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<div style="clear:both"></div>
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[[Category: Nedyalkova, L.]]
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__TOC__
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[[Category: Park, H.]]
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</StructureSection>
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Human]]
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[[Category: Tempel, W.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Tong, Y.]]
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[[Category: Bochkarev, A]]
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[[Category: Wang, H.]]
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[[Category: Bountra, C]]
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[[Category: Weigelt, J.]]
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[[Category: Crombet, L]]
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[[Category: Edwards, A M]]
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[[Category: Guan, X]]
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[[Category: Nedyalkova, L]]
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[[Category: Park, H]]
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[[Category: Structural genomic]]
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[[Category: Tempel, W]]
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[[Category: Tong, Y]]
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[[Category: Wang, H]]
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[[Category: Weigelt, J]]
[[Category: Guanine-nucleotide releasing factor]]
[[Category: Guanine-nucleotide releasing factor]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
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[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 

Revision as of 09:05, 17 December 2014

Crystal structure of the second BRCT domain of epithelial cell transforming 2 (ECT2)

3l46, resolution 1.48Å

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