Urokinase
From Proteopedia
(Difference between revisions)
| Line 6: | Line 6: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *Urokinase | |
| - | [[2i9a]] - hUK Hc N terminal (residues 21-163) - human<br /> | + | **[[2i9a]] - hUK Hc N terminal (residues 21-163) - human<br /> |
| - | [[1kdu]] – hUK kringle domain (residues 69-153) - NMR<br /> | + | **[[1kdu]] – hUK kringle domain (residues 69-153) - NMR<br /> |
| - | [[4dva]] – hUK catalytic domain (residues 179-431) <br /> | + | **[[4dva]] – hUK catalytic domain (residues 179-431) <br /> |
| - | + | *Urokinase catalytic domain complex with inhibitors | |
| - | [[4fu7]], [[4fu8]], [[4fu9]], [[4fub]] - hUK + inhibitor<br /> | + | **[[4fu7]], [[4fu8]], [[4fu9]], [[4fub]] - hUK + inhibitor<br /> |
| - | [[1fv9]] – hUK (mutant) + benzimidazole derivative – human<br /> | + | **[[1fv9]] – hUK (mutant) + benzimidazole derivative – human<br /> |
| - | [[1f5k]] - hUK (mutant) + benzamidine derivative<br /> | + | **[[1f5k]] - hUK (mutant) + benzamidine derivative<br /> |
| - | [[1f5l]] - hUK (mutant) + amiloride derivative<br /> | + | **[[1f5l]] - hUK (mutant) + amiloride derivative<br /> |
| - | [[1f92]], [[1sc8]], [[1vj9]], [[1vja]], [[2o8t]], [[2o8u]], [[2o8w]], [[4h42]] - hUK (mutant) + inhibitor<br /> | + | **[[1f92]], [[1sc8]], [[1vj9]], [[1vja]], [[2o8t]], [[2o8u]], [[2o8w]], [[4h42]] - hUK (mutant) + inhibitor<br /> |
| - | [[1owd]], [[1owe]], [[1owh]], [[1owi]], [[1owj]], [[1owk]], [[1sqa]], [[1sqo]], [[1u6q]], [[1sqt]], [[4fuc]], [[4fud]], [[4fue]], [[4fuf]], [[4fug]], [[4fuh]], [[4fui]], [[4fuj]]- hUK + naphthamidine inhibitor<br /> | + | **[[1owd]], [[1owe]], [[1owh]], [[1owi]], [[1owj]], [[1owk]], [[1sqa]], [[1sqo]], [[1u6q]], [[1sqt]], [[4fuc]], [[4fud]], [[4fue]], [[4fuf]], [[4fug]], [[4fuh]], [[4fui]], [[4fuj]]- hUK + naphthamidine inhibitor<br /> |
| - | [[1ejn]] - hUK (mutant) + urea derivative inhibitor<br /> | + | **[[1ejn]] - hUK (mutant) + urea derivative inhibitor<br /> |
| - | [[2vin]], [[2vio]], [[2vip]], [[2viq]], [[2viv]], [[2viw]] - hUK (mutant) + mexiletine derivative<br /> | + | **[[2vin]], [[2vio]], [[2vip]], [[2viq]], [[2viv]], [[2viw]] - hUK (mutant) + mexiletine derivative<br /> |
| - | [[3qn7]], [[4jk5]], [[4jk6]] - hUK (mutant) + peptide inhibitor<br /> | + | **[[3qn7]], [[4jk5]], [[4jk6]] - hUK (mutant) + peptide inhibitor<br /> |
| - | [[2vnt]], [[2r2w]] - hUK + guanidine derivative<br /> | + | **[[2vnt]], [[2r2w]] - hUK + guanidine derivative<br /> |
| - | [[1w0z]], [[1w10]], [[1w11]], [[1w12]], [[1w13]], [[1w14]] - hUK + alanineamide derivative<br /> | + | **[[1w0z]], [[1w10]], [[1w11]], [[1w12]], [[1w13]], [[1w14]] - hUK + alanineamide derivative<br /> |
| - | + | *Urokinase C terminal complex with inhibitors | |
| - | [[3kgp]] – hUK Hc C terminal (mutant) + benzoic acid derivative<br /> | + | **[[3kgp]] – hUK Hc C terminal (mutant) + benzoic acid derivative<br /> |
| - | [[3khv]] - hUK Hc C terminal (mutant) + methanol derivative<br /> | + | **[[3khv]] - hUK Hc C terminal (mutant) + methanol derivative<br /> |
| - | [[3mwi]] - hUK Hc C terminal (mutant) + amidine derivative<br /> | + | **[[3mwi]] - hUK Hc C terminal (mutant) + amidine derivative<br /> |
| - | [[3ox7]], [[3oy5]], [[3oy6]] - hUK Hc C terminal (mutant) + peptide inhibitor<br /> | + | **[[3ox7]], [[3oy5]], [[3oy6]] - hUK Hc C terminal (mutant) + peptide inhibitor<br /> |
| - | [[3kid]], [[3mhw]] - hUK Hc C terminal (mutant) + aminobenzothiazole derivative<br /> | + | **[[3kid]], [[3mhw]] - hUK Hc C terminal (mutant) + aminobenzothiazole derivative<br /> |
| - | [[2nwn]], [[4gly]] - hUK Hc C terminal + cyclic peptide<br /> | + | **[[2nwn]], [[4gly]] - hUK Hc C terminal + cyclic peptide<br /> |
| - | [[3m61]] - hUK Hc C terminal (mutant) + cyclic peptide | + | **[[3m61]] - hUK Hc C terminal (mutant) + cyclic peptide |
| - | + | *Urokinase short chain + catalytic domain complex with inhibitors | |
| - | [[1lmw]] – hUK A+B catalytic domain + EGRCMK<br /> | + | **[[1lmw]] – hUK A+B catalytic domain + EGRCMK<br /> |
| - | [[1c5w]], [[1c5x]], [[1c5y]], [[1c5z]] - hUK A+B chain catalytic domain + carboxamidine derivative<br /> | + | **[[1c5w]], [[1c5x]], [[1c5y]], [[1c5z]] - hUK A+B chain catalytic domain + carboxamidine derivative<br /> |
| - | [[1gi7]], [[1gi8]], [[1gi9]], [[1gj7]], [[1gj8]], [[1gj9]], [[1gja]], [[1gjb]], [[1gjc]], [[1gjd]] - hUK A+B chain catalytic domain (mutant) + carboxamidine derivative<br /> | + | **[[1gi7]], [[1gi8]], [[1gi9]], [[1gj7]], [[1gj8]], [[1gj9]], [[1gja]], [[1gjb]], [[1gjc]], [[1gjd]] - hUK A+B chain catalytic domain (mutant) + carboxamidine derivative<br /> |
| - | [[1o3p]], [[1o5a]], [[1o5b]], [[1o5c]] - hUK A+B chain catalytic domain (mutant) + benzenolate derivative<br /> | + | **[[1o3p]], [[1o5a]], [[1o5b]], [[1o5c]] - hUK A+B chain catalytic domain (mutant) + benzenolate derivative<br /> |
| - | [[3ig6]] – hUK A+B chain catalytic domain + inhibitor<br /> | + | **[[3ig6]] – hUK A+B chain catalytic domain + inhibitor<br /> |
| - | + | *Urokinase complex with protein | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| + | **[[2fd6]] – hUK Hc N terminal + antibody + UK receptor<br /> | ||
| + | **[[3bt1]], [[3bt2]] - hUK Hc N terminal + vitronectin + UK receptor<br /> | ||
| + | **[[3laq]], [[3u73]] - hUK Hc N terminal + UK receptor<br /> | ||
| + | **[[3pb1]] - hUK Hc C terminal (mutant) + UK inhibitor<br /> | ||
| + | **[[2i9b]] - hUK Hc N terminal + UK receptor (mutant)<br /> | ||
| + | **[[4dw2]] - hUK B chain catalytic domain + antibody<br /> | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:43, 17 December 2014
Urokinase (UK) is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin. UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains. Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage into catalytic domain (residues 179-431) and short chain (residues 156-178).
3D Structures of urokinase
Updated on 17-December-2014
