1owt

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[[Image:1owt.jpg|left|200px]]<br /><applet load="1owt" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1owt.jpg|left|200px]]
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caption="1owt" />
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'''Structure of the Alzheimer's disease amyloid precursor protein copper binding domain'''<br />
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{{Structure
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|PDB= 1owt |SIZE=350|CAPTION= <scene name='initialview01'>1owt</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= APP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Structure of the Alzheimer's disease amyloid precursor protein copper binding domain'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1OWT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1OWT with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWT OCA].
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1OWT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1OWT with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWT OCA].
==Reference==
==Reference==
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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis., Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R, J Biol Chem. 2003 May 9;278(19):17401-7. Epub 2003 Feb 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12611883 12611883]
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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis., Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R, J Biol Chem. 2003 May 9;278(19):17401-7. Epub 2003 Feb 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12611883 12611883]
[[Category: Amyloid-beta Precursor Protein]]
[[Category: Amyloid-beta Precursor Protein]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: beta-alpha-beta-beta]]
[[Category: beta-alpha-beta-beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:22:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:16:43 2008''

Revision as of 11:16, 20 March 2008

Image:1owt.jpg


PDB ID 1owt

Drag the structure with the mouse to rotate
Gene: APP (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Structure of the Alzheimer's disease amyloid precursor protein copper binding domain


Contents

Overview

A major source of free radical production in the brain derives from copper. To prevent metal-mediated oxidative stress, cells have evolved complex metal transport systems. The Alzheimer's disease amyloid precursor protein (APP) is a major regulator of neuronal copper homeostasis. APP knockout mice have elevated copper levels in the cerebral cortex, whereas APP-overexpressing transgenic mice have reduced brain copper levels. Importantly, copper binding to APP can greatly reduce amyloid beta production in vitro. To understand this interaction at the molecular level we solved the structure of the APP copper binding domain (CuBD) and found that it contains a novel copper binding site that favors Cu(I) coordination. The surface location of this site, structural homology of CuBD to copper chaperones, and the role of APP in neuronal copper homeostasis are consistent with the CuBD acting as a neuronal metallotransporter.

Disease

Known diseases associated with this structure: Alzheimer disease-1, APP-related OMIM:[104760], Amyloidosis, cerebroarterial, Dutch type OMIM:[104760], Amyloidosis, cerebroarterial, Iowa type OMIM:[104760], Blood group, P system OMIM:[607922]

About this Structure

1OWT is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1OWT with [Amyloid-beta Precursor Protein]. Full crystallographic information is available from OCA.

Reference

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis., Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R, J Biol Chem. 2003 May 9;278(19):17401-7. Epub 2003 Feb 28. PMID:12611883

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