Vinculin
From Proteopedia
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *Vinculin | |
| - | [[3h2u]] – hVCL Vd1 + raver1 RRM - human<br /> | + | **[[3h2u]] – hVCL Vd1 + raver1 RRM - human<br /> |
| - | [[3h2v]] - hVCL C-terminal + raver1 RRM<br /> | + | **[[3h2v]] - hVCL C-terminal + raver1 RRM<br /> |
| - | [[2ibf]], [[2hsq]], [[2gww]] - hVCL Vd1 + SfVCL binding sites from ''Shigella flexneri''<br /> | + | **[[2ibf]], [[2hsq]], [[2gww]] - hVCL Vd1 + SfVCL binding sites from ''Shigella flexneri''<br /> |
| - | [[1tr2]] – hVCL<br /> | + | **[[1tr2]] – hVCL<br /> |
| - | [[1ydi]] - hVCL Vd1+hActinin VBS<br /> | + | **[[1ydi]] - hVCL Vd1+hActinin VBS<br /> |
| - | [[1t01]] - cVCL Vd1+mTalin VBS – chicken<br /> | + | **[[1t01]] - cVCL Vd1+mTalin VBS – chicken<br /> |
| - | [[1syq]], [[1rkc]], [[1rke]] – hVCL Vd1+hTalin VBS<br /> | + | **[[1syq]], [[1rkc]], [[1rke]] – hVCL Vd1+hTalin VBS<br /> |
| - | [[1qkr]] – hVCL C-terminal<br /> | + | **[[1qkr]] – hVCL C-terminal<br /> |
| - | [[3zdl]] – cVCL Vd1 + amyloid β precursor protein N terminal<br /> | + | **[[3zdl]] – cVCL Vd1 + amyloid β precursor protein N terminal<br /> |
| - | + | *Metavinculin | |
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| + | **[[3myi]] – m-VCL tail domain <br /> | ||
| + | **[[3rf3]] - hm-VCL + invasin IPAA<br /> | ||
| + | **[[3s90]] - hm-VCL head domain + mTalin-1 peptide<br /> | ||
| + | **[[4dj9]] - hm-VCL head domain + hTalin-1 peptide <br /> | ||
| + | **[[3tj5]] - hm-VCL head domain + Sca-family protein peptide<br /> | ||
| + | **[[3tj6]] - hm-VCL head domain + protein Ps 120 peptide<br /> | ||
| + | **[[4ehp]] - hm-VCL head domain + catenin α-1 residues 277-382<br /> | ||
| + | **[[3vf0]] – hm-VCL residues 856-1134 + ribonucleoprotein PTB-binding<br /> | ||
| + | **[[2gdc]] – cm-VCL Vd1+SfInvasin C-terminal <br /> | ||
| + | **[[1xwj]] - cm-VCL Vd1+cTalin VBS3<br /> | ||
| + | **[[1zvz]], [[1zw2]], [[1zw3]], [[1u6h]] - cm-VCL Vd1+cTalin rod<br /> | ||
| + | **[[1st6]] – cm-VCL<br /> | ||
| + | **[[4e17]], [[4e18]] - cm-VCL Vd1 + catenin α-1 VCL-binding domain | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
*Created with the participation of [[User:Susan Craig|Susan Craig]]. | *Created with the participation of [[User:Susan Craig|Susan Craig]]. | ||
Revision as of 10:15, 17 December 2014
Vinculins (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to talin or to alpha-actinin at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. The images at the left and at the right correspond to one representative Vinculin structure, i.e. crystal structure of human full-length Vinculin (1tr2). is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains (1st6). Energetically, I997 is key to maintaining this autoinhibition. Metavinculin is a splice version of VCL containing an extra ca. 70 amino acids in the C-terminal domain.
3D Structures of Vinculin
Updated on 17-December-2014
- Created with the participation of Susan Craig.
