1oyt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1oyt.jpg|left|200px]]<br /><applet load="1oyt" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1oyt.jpg|left|200px]]
-
caption="1oyt, resolution 1.67&Aring;" />
+
 
-
'''COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR'''<br />
+
{{Structure
 +
|PDB= 1oyt |SIZE=350|CAPTION= <scene name='initialview01'>1oyt</scene>, resolution 1.67&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=FSN:(3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINE'>FSN</scene>
 +
|ACTIVITY= [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]
 +
|GENE= F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
}}
 +
 
 +
'''COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR'''
 +
 
==Disease==
==Disease==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1OYT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=FSN:'>FSN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYT OCA].
+
1OYT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYT OCA].
==Reference==
==Reference==
-
A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions., Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Muller K, Diederich F, Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12800172 12800172]
+
A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions., Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Muller K, Diederich F, Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12800172 12800172]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
Line 21: Line 30:
[[Category: hydrolase (serine proteinase)]]
[[Category: hydrolase (serine proteinase)]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:23:23 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:17:30 2008''

Revision as of 11:17, 20 March 2008

Image:1oyt.jpg


PDB ID 1oyt

Drag the structure with the mouse to rotate
, resolution 1.67Å
Ligands: , and
Gene: F2 (Homo sapiens)
Activity: Thrombin, with EC number 3.4.21.5
Coordinates: save as pdb, mmCIF, xml



COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR


Disease

Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

1OYT is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions., Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Muller K, Diederich F, Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. PMID:12800172

Page seeded by OCA on Thu Mar 20 13:17:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1oyt"
Personal tools