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1oyt

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[[Image:1oyt.jpg|left|200px]]<br /><applet load="1oyt" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1oyt.jpg|left|200px]]
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caption="1oyt, resolution 1.67&Aring;" />
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'''COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR'''<br />
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{{Structure
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|PDB= 1oyt |SIZE=350|CAPTION= <scene name='initialview01'>1oyt</scene>, resolution 1.67&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=FSN:(3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINE'>FSN</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]
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|GENE= F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR'''
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==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1OYT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=FSN:'>FSN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYT OCA].
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1OYT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYT OCA].
==Reference==
==Reference==
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A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions., Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Muller K, Diederich F, Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12800172 12800172]
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A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions., Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Muller K, Diederich F, Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12800172 12800172]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: hydrolase (serine proteinase)]]
[[Category: hydrolase (serine proteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:23:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:17:30 2008''

Revision as of 11:17, 20 March 2008

Image:1oyt.jpg


PDB ID 1oyt

Drag the structure with the mouse to rotate
, resolution 1.67Å
Ligands: , and
Gene: F2 (Homo sapiens)
Activity: Thrombin, with EC number 3.4.21.5
Coordinates: save as pdb, mmCIF, xml



COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR


Disease

Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

1OYT is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions., Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Muller K, Diederich F, Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. PMID:12800172

Page seeded by OCA on Thu Mar 20 13:17:30 2008

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