1ozn

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[[Image:1ozn.jpg|left|200px]]<br /><applet load="1ozn" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ozn.jpg|left|200px]]
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caption="1ozn, resolution 1.52&Aring;" />
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'''1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination'''<br />
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{{Structure
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|PDB= 1ozn |SIZE=350|CAPTION= <scene name='initialview01'>1ozn</scene>, resolution 1.52&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
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|ACTIVITY=
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|GENE= RTN4R OR NOGOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1OZN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZN OCA].
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1OZN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZN OCA].
==Reference==
==Reference==
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Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition., He XL, Bazan JF, McDermott G, Park JB, Wang K, Tessier-Lavigne M, He Z, Garcia KC, Neuron. 2003 Apr 24;38(2):177-85. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12718853 12718853]
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Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition., He XL, Bazan JF, McDermott G, Park JB, Wang K, Tessier-Lavigne M, He Z, Garcia KC, Neuron. 2003 Apr 24;38(2):177-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12718853 12718853]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: signal transduction]]
[[Category: signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:23:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:17:49 2008''

Revision as of 11:17, 20 March 2008

Image:1ozn.jpg


PDB ID 1ozn

Drag the structure with the mouse to rotate
, resolution 1.52Å
Ligands:
Gene: RTN4R OR NOGOR (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination


Contents

Overview

Failure of axon regeneration in the adult mammalian central nervous system (CNS) is at least partly due to inhibitory molecules associated with myelin. Recent studies suggest that an axon surface protein, the Nogo receptor (NgR), may play a role in this process through an unprecedented degree of crossreactivity with myelin-associated inhibitory ligands. Here, we report the 1.5 A crystal structure and functional characterization of a soluble extracellular domain of the human Nogo receptor. Nogo receptor adopts a leucine-rich repeat (LRR) module whose concave exterior surface contains a broad region of evolutionarily conserved patches of aromatic residues, possibly suggestive of degenerate ligand binding sites. A deep cleft at the C-terminal base of the LRR may play a role in NgR association with the p75 coreceptor. These results now provide a detailed framework for focused structure-function studies aimed at assessing the physiological relevance of NgR-mediated protein-protein interactions to axon regeneration inhibition.

Disease

Known diseases associated with this structure: Schizophrenia, susceptibility to OMIM:[605566]

About this Structure

1OZN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition., He XL, Bazan JF, McDermott G, Park JB, Wang K, Tessier-Lavigne M, He Z, Garcia KC, Neuron. 2003 Apr 24;38(2):177-85. PMID:12718853

Page seeded by OCA on Thu Mar 20 13:17:49 2008

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