3wvf
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Crystal structure of YidC from Escherichia coli== |
| + | <StructureSection load='3wvf' size='340' side='right' caption='[[3wvf]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3wvf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WVF FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wvf RCSB], [http://www.ebi.ac.uk/pdbsum/3wvf PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bacterial YidC, an evolutionally conserved membrane protein, functions as a membrane protein chaperone in cooperation with the Sec translocon and as an independent insertase for membrane proteins. In Gram-negative bacteria, the transmembrane and periplasmic regions of YidC interact with the Sec proteins, forming a multi-protein complex for Sec-dependent membrane protein integration. Here, we report the crystal structure of full-length Escherichia coli YidC. The structure reveals that a hydrophilic groove, formed by five transmembrane helices, is a conserved structural feature of YidC, as compared to the previous YidC structure from Bacillus halodurans, which lacks a periplasmic domain. Structural mapping of the substrate- or Sec protein-contact sites suggested the importance of the groove for the YidC functions as a chaperone and an insertase, and provided structural insight into the multi-protein complex. | ||
| - | + | Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase.,Kumazaki K, Kishimoto T, Furukawa A, Mori H, Tanaka Y, Dohmae N, Ishitani R, Tsukazaki T, Nureki O Sci Rep. 2014 Dec 3;4:7299. doi: 10.1038/srep07299. PMID:25466392<ref>PMID:25466392</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ishitani, R]] | ||
| + | [[Category: Kishimoto, T]] | ||
| + | [[Category: Kumazaki, K]] | ||
| + | [[Category: Nureki, O]] | ||
| + | [[Category: Tsukazaki, T]] | ||
| + | [[Category: Alpha helical]] | ||
| + | [[Category: Chaperone]] | ||
Revision as of 12:40, 17 December 2014
Crystal structure of YidC from Escherichia coli
| |||||||||||
