4wl9
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Time Resolved Serial Femtosecond Crystallography Captures High Resolution Intermediates of PYP== |
| + | <StructureSection load='4wl9' size='340' side='right' caption='[[4wl9]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4wl9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WL9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wla|4wla]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wl9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wl9 RCSB], [http://www.ebi.ac.uk/pdbsum/4wl9 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Serial femtosecond crystallography using ultrashort pulses from x-ray free electron lasers (XFELs) enables studies of the light-triggered dynamics of biomolecules. We used microcrystals of photoactive yellow protein (a bacterial blue light photoreceptor) as a model system and obtained high-resolution, time-resolved difference electron density maps of excellent quality with strong features; these allowed the determination of structures of reaction intermediates to a resolution of 1.6 angstroms. Our results open the way to the study of reversible and nonreversible biological reactions on time scales as short as femtoseconds under conditions that maximize the extent of reaction initiation throughout the crystal. | ||
| - | + | Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein.,Tenboer J, Basu S, Zatsepin N, Pande K, Milathianaki D, Frank M, Hunter M, Boutet S, Williams GJ, Koglin JE, Oberthuer D, Heymann M, Kupitz C, Conrad C, Coe J, Roy-Chowdhury S, Weierstall U, James D, Wang D, Grant T, Barty A, Yefanov O, Scales J, Gati C, Seuring C, Srajer V, Henning R, Schwander P, Fromme R, Ourmazd A, Moffat K, Van Thor JJ, Spence JC, Fromme P, Chapman HN, Schmidt M Science. 2014 Dec 5;346(6214):1242-6. doi: 10.1126/science.1259357. PMID:25477465<ref>PMID:25477465</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Schmidt, M]] | ||
| + | [[Category: Tenboer, J]] | ||
| + | [[Category: Blue-light photoreceptor]] | ||
| + | [[Category: Dark structure]] | ||
| + | [[Category: Microcrystal]] | ||
| + | [[Category: Nanocrystal]] | ||
| + | [[Category: Time-resolved serial femtosecond crystallography]] | ||
Revision as of 12:50, 17 December 2014
Time Resolved Serial Femtosecond Crystallography Captures High Resolution Intermediates of PYP
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